Microfluidics for Chemistry and Cellbiology

Mission

The research group is focused on the application of microfluidics to chemistry and cell biology. The team, which consists of a chemist, a physicist, a biotechnologist, a material engineer and a technician, is strongly interdisciplinary. During the years, the fabrication of microreactors as well as the fine-tuning of the operating conditions to produce nanoformulations have been the relevant target of the group activity. Thanks to expertise in the dynamics of fluids in confined environment and the fabrication of integrated lab-on-chip, the physical/chemical properties and functionalities of (bio)molecules and (bio)materials have been deeply investigated and finely addressed. Recently two biologists joined the microfluidics team, thus the group is also moving towards cell biology in the perspective of using microfluidic technologies to create biomimetic niches and study pathophysiological phenomena with high parametric control. All these activities are currently supported by active projects

People Involved

Arima

Valentina

CNR Researcher

Group Coordinator 

Monica

Bianco

CNR PostDoc

Elisabetta

Perrone

CNR Technician

Ilenia

Viola

CNR Researcher

Alessandra

Zizzari

Associate PHD Student

Antonio

Gaballo

CNR Researcher

Paola

Priore

CNR PostDoc

Facilities & Labs

Characterization Lab @ Lecce

Bio Lab @ Lecce

NanoFab Lab @ Lecce

Soft and Living Matter Laboratory @ Rome

Linee di Ricerca

Nanobiotechnology

Lab on chip
Biosensors & Bioelectronics
Cell biology

Photonics&Optoelectronics

Organic Random Lasers

Publications

  1. M. Bianco, A. Sonato, A. De Girolamo, M. Pascale, F. Romanato, R. Rinaldi, V. Arima An aptamer-based SPR-polarization platform for high sensitive OTA detection Sensors & Actuators: B. Chemical 314-320 (2017) ISSN: 0925-4005; doi: 10.1016/j.snb.2016.10.056
  2. M. S. Chiriacò, M. Bianco, F. Amato, E. Primiceri, F. Ferrara, V. Arima, G. Maruccio Fabrication of interconnected multilevel channels in a monolithic SU-8 structure using a LOR sacrificial layer Microelectronic Engineering 164, 1, 30-35 (2016) ISSN: 01679317DOI: 10.1016/j.mee.2016.07.006
  3. F. Di Maria, M. Zangoli, I. E. Palamá, E. Fabiano, A. Zanelli, M. Monari, A. Perinot, M. Caironi, V. Maiorano, A. Maggiore, M. Pugliese, E. Salatelli, G. Gigli, I. Viola, G. Barbarella Improving the Property–Function Tuning Range of Thiophene Materials via Facile Synthesis of Oligo/Polythiophene-S-Oxides and Mixed Oligo/Polythiophene-S-Oxides/Oligo/Polythiophene-S,S-Dioxides  Adv. Funct. Mater. 26 (38), 6970-6984 (2016) ISSN:1616-3028 DOI: 10.1002/adfm.201602996.
  4. D. Vergara, P. Simeone, F. Julien, M. Trerotola, A. Giudetti, L. Capobianco, A. Tinelli, C. Bellomo,
I. Fournie, A. Gaballo, S. Alberti, M. Salzet, M. Maffia, Translating epithelial mesenchymal transition markers into the clinic: Novel insights from proteomics EuPA Open Proteomics, 10, 31-41, (2016) ISSN: 2212-9685 doi:10.1016/j.euprot.2016.01.003
  5. M. Bianco, V. Guarino, G. Maruccio, G. Galli, E. Martinelli, G. Montani, R. Rinaldi and V. Arima Non-Biofouling Fluorinated Block Copolymer Coatings for Contact Lenses Sci. Adv. Mater. 7, 1387-1394 (2015). ISSN: 1947-2935; doi: 10.1166/sam.2015.2056
  6. A. Zacheo, A. Quarta,  A. Zizzari,   A. G. Monteduro,   G. Maruccio,  V. Arima and   G. Gigli One step preparation of quantum dot-embedded lipid nanovesicles by a microfluidic device RSC Adv., 5, 98576-98582 (2015) ISSN: 2046-2069; doi: 10.1039/c5ra18862h
  7. A .Zacheo, A. Zizzari, E. Perrone, L. Carbone, G. Giancane, L. Valli, R. Rinaldi and V. Arima Fast and safe microwave-assisted glass channel shaped microstructure fabrication Lab Chip 15, 2395–2399 (2015) ISSN: 1473-0197; doi: 1039/c4lc01419g
  8. V. Arima, P. Watts, and G. Pascali Microfluidics in Planar Microchannels: Synthesis of Chemical Compounds On-Chip Chapter 8 from “Lab-on-a-Chip Devices and Micro-Total Analysis Systems: A Practical Guide” Published: November 5, 2014 by Springer. Editor(s): by Jaime Castillo-León and Winnie E. Svendsen
  9. A .Zizzari,   M. Bianco,   R. Miglietta, L. L. del Mercato, M. Carraro, A. Sorarù, M. Bonchio, G. Gigli, R. Rinaldi, I. Viola, V. Arima, Catalytic oxygen production mediated by smart capsules to modulate elastic turbulence under a laminar flow regime Lab Chip, 14, 4391-4397 (2014) ISSN: 1473-0197; doi: 1039/c4lc00791c
  10. L. del Mercato, M. Carraro, A. Zizzari, M. Bianco, R. Miglietta, V. Arima, I. Viola, C. Nobile, A. Sorar, D. Vilona, G. Gigli, M. Bonchio, R. Rinaldi Catalytic Self-Propulsion of Supramolecular Capsules Powered by Polyoxometalate Cargos Chem. Eur. J. 20, 1 – 6 (2014) ISSN: 0947-6539; doi: 10.1002/chem.201403171

Oldest publications (2011-2013):

  1. I. Viola, N. Ghofraniha, A. Zacheo, V. Arima,  C. Conti, G. Gigli Random laser emission from a paper-based device J. Mat. Chem. C 1, 8128-8133 (2013) ISSN: 2050-7526; doi: 10.1039/c3tc31860e
  2. V. Arima,   G, Pascali,  O. Lade,  H. R. Kretschmer,   I. Bernsdorf,   V. Hammond,  P. Watts,   F. De Leonardis,   M. D. Tarn,  N. Pamme,   B. Z. Cvetkovic,   P. S. Dittrich,   N. Vasovic,   R. Duane,   A. Jaksic,   A. Zacheo,   A. Zizzari,   L. Marra,  E. Perrone,  P. A. Salvadori,   R. Rinaldi Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals Lab on a chip 13, 2328-2336 (2013) ISSN: 1473-0197; doi: 10.1039/c3lc00055a
  3. R. Milani, E. Monogioudi, M. Baldrighi, Cavallo, V. Arima, L. Marra, A. Zizzari, R. Rinaldi, M- Linder, G. Resnati, P. Metrangolo Hydrophobin: fluorosurfactant-like properties without fluorine Soft Matter 9, 6505-6514 (2013) ISSN: 1744683X; doi: 10.1039/c3sm51262b
  4. N. Ghofraniha, I. Viola, A. Zacheo, V. Arima, G. Gigli, C. Conti   Transition from nonresonant to resonant random lasers by the geometrical confinement of disorder Opt. Lett. 38, 5043-5046  (2013) ISSN: 0146-9592; doi: 10.1364/OL.38.005043
  5. M. Bianco, A. Aloisi, V. Arima, M. Capello, S. Ferri-Borgogno, F. Novelli, S. Leporatti and R. Rinaldi Quartz Crystal Microbalance with Dissipation (QCM-D) as tool to exploit antigen-antibody interactions in pancreatic ductal adenocarcinoma detection Biosensors and Bioelectronics 42, 646–652 (2013) ISSN: 0956-5663; doi: 10.1016/j.bios.2012.10.012
  6. B. Z. Cvetković, O. Lade, L. Marra, V. Arima, R. Rinaldi and P. S. Dittrich Nitrogen supported solvent evaporation using continuous-flow microfluidicsRSC Adv. 2, 11117-11122 (2012) ISSN: 20462069; doi: 10.1039/c2ra21876c
  7. V. Arima, M. Bianco, A. Zacheo, A. Zizzari, E. Perrone, L. Marra, R. Rinaldi Fluoropolymers coatings on polydimethylsiloxane for retarding swelling in toluene Thin Solid Films 520, 2293–2300 (2012). ISSN: 0040-6090; doi: 10.1016/j.tsf.2011.09.063
  8. I. Viola, A. Zacheo, V. Arima, A. S. Aricò, B. Cortese, M. Manca, A. Zocco, A. Taurino, R. Rinaldi, G. Gigli The influence of polydimethylsiloxane curing ratio on capillary pressure in microfluidic devices Appl. Surf. Sci. 258, 8032-8039 (2012) ISSN: 0169-4332; doi: 10.1016/j.apsusc.2012.04.164
  9. M. Bianco, I. Viola, M. Cezza, F. Pietracaprina, G. Gigli, R. Rinaldi, V. Arima Microfluidic motion for a direct investigation of solvent interactions with PDMS microchannels Microfluid. Nanofluid. 13, 399-409 (2012) ISSN: 1613-4982; doi: 10.1007/s10404-012-0966-y
  10. G. Montani, V. Arima, G. Maruccio, The Tear Film Interaction with Contact Lenses Chapter 19 from “Ocular surface: Anatomy and Physiology, Disorders and Therapeutic Care” Published: October 18, 2012 by CRC Press. Editor(s): Raul Martin Herranz, University of Valladolid, Spain; Rosa M. Corrales Herran, Baylor College of Medicine, Houston, Texas, USA.
  11. A. Zacheo, V. Arima, G. Pascali, P.A. Salvadori, A. Zizzari, E. Perrone, L. De Marco, G. Gigli, R. Rinaldi, Radioactivity resistance evaluation of polymeric materials for application in radiopharmaceutical production at microscale Microfluid. Nanofluid. 11 (1), 35-44 (2011) ISSN: 1613-4982; doi: 10.1007/s10404-011-0770-0
  12. A. Zizzari, V. Arima, A. Zacheo, G. Pascali, P.A. Salvadori, E. Perrone, D. Mangiullo, R. Rinaldi Fabrication of SU-8 microreactors for radiopharmaceutical production Microelectronic Engineering 88   (8), 1664-1667 (2011) ISSN: 0167-9317; doi: 10.1016/j.mee.2010.12.059

Projects

Cluster in Bioimaging – Regione Puglia Bando “Aiuti a Sostegno Cluster Tecnologici Regionali” (2015-2017). PI: Valentina Arima

SISTEMA – Sviluppo di nuove metodologie e strumenti Innovativi per la diagnoSi ed il trattamento Terapeutico di tumori Epiteliali uMAni. Regione Puglia Bando “Aiuti a Sostegno Cluster Tecnologici Regionali” (2015-2017) PI: Antonio Gaballo

Latest News

  • Loretta del Mercato, si aggiudica l’ERC STARTING GRANT 2017

    Loretta del Mercato, si aggiudica  l’ERC STARTING GRANT 2017

    uno dei bandi più competitivi a livello europeo.

    Lecce, 6 settembre 2017 

    Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

    (more…)
  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

Particle – Based Plasma Virtual Lab

Mission

Development of models, at different time scales and length, based on the particle representation (Particle-in-Cell, Monte Carlo and Molecular Dynamics) gas / plasma non-equilibrium systems for applications in the aerospace, energy and materials science

People Involved

Francesco

Taccogna

CNR Researcher

Group Coordinator 

Domenico

Bruno

CNR Researcher

Pierpaolo

Minelli

CNR Researcher

Maria

Rutigliano

CNR Researcher

Facilities & Labs

HPC Cluster and Services @ Bari

Linee di Ricerca

Publications

  1. F. Taccogna, R. Schneider, S. Longo, M. Capitelli, Kinetic simulations of plasma thrusters, Plasma Source Sci. and Technol., 17, 024003, (2008) ISNN: 0963-0252; doi: 10.1088/0963-0252/17/2/024003
  2. F. Taccogna, S. Longo, M. Capitelli, R. Schneider, Anomalous Transport induced by Sheath Instability in Hall Effect Thrusters, Applied Physics Letters, 94, (251502), (2009) ISNN: 0003-6951; doi: 10.1063/1.3152270
  3. F. Taccogna, P. Minelli, S. Longo, M. Capitelli, R. Schneider, Modeling of a negative ion source III. Two-dimensional structure of the extraction region, Phys. Plasmas 17, 063502, (2010) ISNN: 1070-664X; doi: 10.1063/1.3431635
  4. F. Taccogna, P. Minelli, S. Longo, Three-dimensional structure of the extraction region of a hybrid negative ion source, Plasma Sources Sci. and Technol., 22, 045019, (2013) ISNN: 0963-0252; doi: 10.1088/0963-0252/22/4/045019
  5. N. Oudini, N. Sirse, F. Taccogna, A. R. Ellingboe and A. Bendib, Photo-detachment signal analysis to accurately determine electronegativity, electron temperature, and charged species density, Appl. Phys. Lett. 109, 124101 (2016); doi: 10.1063/1.4963138
  6. Maria Rutigliano, Fernando Pirani, Selectivity in the inelastic rotational scattering of hydrogen molecules from graphite, Chem. Phys., 479, 11–19, (2016), doi:10.1016/j.chemphys.2016.09.002
  7. Maria Rutigliano, Nico Sanna, Amedeo Palma, Multiple approach to model unpaired spin density effects in H-ZSM5 zeolite with extra-framework O atom: H-abstraction reaction from methane, Computational and Theoretical Chemistry, 1074, 9-18, (2015), doi: 10.1016/j.comptc.2015.10.002
  8. M. Rutigliano, P. Gamallo, R. Sayós, S. Orlandini, and M. Cacciatore, A molecular dynamics simulation of hydrogen atoms collisions on an H-preadsorbed silica surface, Plasma Sources Science and Technology, 23, 045016, (2014), doi: 10.1088/0963-0252/23/4/045016
  9. M. Rutigliano, D. Santoro, M. Balat-Pichelin, Hydrogen atom recombination on tungsten at high temperature: Experiment and Molecular Dynamics Simulation, Surface Science, 628, 66-75, (2014), doi: 10.1016/j.susc.2014.05.007
  10. Costantino Zazza, Maria Rutigliano, Nico Sanna, Vincenzo Barone, Mario Cacciatore, Oxygen Adsorption on b-Quartz Model Surfaces: Some Insights from Density Functional Theory Calculations and Semiclassical Time-Dependent Dynamics, J. Phys. Chem. A, 116, 1975−1983, (2012), doi: 10.1021/jp205517j
  11. C.M. Coppola, G. Mizzi, D. Bruno, F. Esposito, D. Galli, F. Palla, S. Longo, State-to-state vibrational kinetics of H2 and H2+ in a post-shock cooling gas with primordial composition, MNRAS, 457, 3732-3742, (2016), doi: 10.1093/mnras/stw198
  12. D. Bruno, A. Frezzotti, G.P. Ghiroldi, Oxygen transport properties estimation by classical trajectory-direct simulation Monte Carlo, Phys. Fluids, 27, 057101, (2015), doi: 10.1063/1.4921157
  13. V. Laporta, D. Bruno, Electron-vibration energy exchange models in nitrogen-containing plasma flows, J. Chem. Phys., 138, 104319, (2013), doi: 10.1063/1.4794690
  14. D. Bruno, F. Esposito, V. Giovangigli, Relaxation of rotational-vibrational energy and volume viscosity in H-H2 mixtures, J. Chem. Phys., 138, 084302, (2013), doi: 10.1063/1.4792148
  15. D. Bruno, P. Facchi, S. Longo, P. Minelli, S. Pascazio, A. Scardicchio,  Quantum Zeno Effect in a Model Multilevel Molecule, J. Phys. Chem. A, 113, 14875-14886, (2009), doi: 10.1021/jp9050512

Projects

Apulia Space
G. Colonna, Manager WP A1.6 Space Transport

Latest News

  • Loretta del Mercato, si aggiudica l’ERC STARTING GRANT 2017

    Loretta del Mercato, si aggiudica  l’ERC STARTING GRANT 2017

    uno dei bandi più competitivi a livello europeo.

    Lecce, 6 settembre 2017 

    Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

    (more…)
  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

CeleBra – CELl Engineering BiomateRiAls

Mission
1. Development of biocompatible substrates, through soft lithography techniques, with different gradient stiffness’s and different surface coating for the control of cell motility and adhesion of cancer cells (i.e. glioblastoma)/ healthy cells and bioactive scaffolds to promote cell adhesion, proliferation and differentiation and with particular emphasis on potential applications of such materials in tissue engineering and medicine regenerative.
2. Synthesis of new smart biomaterials, by uptake in living cells of small fluorescent molecules (in collaboration with Dr. G. Barbarella, CNR-ISOF Bologna).
3. Development of new organic/inorganic delivery system for controlled release of active agents, such as drugs and gene.

People Involved

Barbara

Cortese

CNR Researcher

Group Coordinator

Ilaria Elena

Palamà

CNR Researcher

Stefania

D’Amone

 CNR Technician

Facilities & Labs

S.Li.M. Lab @Roma

BioLab @Lecce

Characterization Lab @ Lecce

Nanofab Lab @ Lecce

Research Lines

Publications

  1. Palamà IE, D’Amone S, Arcadio V, Biasiucci M, Mezzi A, Cortese B. Cell mechanotatic and cytoxic response to Zinc oxide nanorods depends on substrate stiffness. Toxicology Research, 2016, 5, 1699-1710, ISSN: 2045-4538, doi:10.1039/C6TX00274A
  2. Di Maria F, Zangoli M, Palamà IE, Fabiano E, Zanelli A, Monari M, Perinot A, Caironi M, Maiorano V, Maggiore A, Pugliese M, Salatelli E, Gigli G, Viola I, Barbarella G. Improving the property-function tuning range of thiophene materials via facile synthesis of oligo/polythiophene-S-oxides and mixed -S-oxides/-S,S-dioxides. Advanced Functional Materials, 2016, DOI: 10.1002/ adfm.201600992.
  3. Toro RG, Caschera D, Palamà IE, D’Amone S, Biasiucci M, Federici F, Gigli G, Cortese B. Unconventional patterning by Solvent-Assisted Surface-tension-driven Lithography. Journal of Colloid and Interface Science, 2015, vol. 446; p. 44-52, ISSN: 0021-9797, doi: 10.1016/j.jcis.2015.01.015
  4. Palamà IE, D’Amone S, Arcadio V, Caschera D, Toro RG, Gigli G, Cortese B. Underwater Wenzel and Cassie Oleophobic behaviour. Journal of Materials Chemistry A, 2015, vol. 3; p. 3854-3861, ISSN: 2050-7496, doi: 1039/C4TA06787H
  5. Caschera D, Toro RG, Federici F, Riccucci C, Ingo GM, Gigli G, Cortese B. Flame retardant properties of plasma pretreated/Diamond-Like Carbon (DLC) coated cotton fabrics. CELLULOSE, 2015, vol. 22; p. 2797-2809, ISSN: 0969-0239, doi: 10.1007/s10570-015-0661-8
  6. Cortese B., D’Amone S, Gigli G, Palamà IE. Sustained anti BCR-ABL activity with pH responsive Imatinib Mesylate loaded PCL nanoparticles in CML cells. Medchemcomm, 2015. vol. 6; p. 212-221, ISSN: 2040-2503, doi: 10.1039/C4MD00348A
  7. Palamà IE, Cortese B., D’Amone S, Arcadio V, Gigli G. Couple delivery of Imatinib Mesylate and Doxorubicin with nanoscaled polymeric vectors for a sustained downregulation of BCR-ABL in Chronic Myeloid Leukemia. Biomaterials Science, 2015. vol. 3; p. 361-372, ISSN: 2047-4830, doi: DOI: 10.1039/C4BM00289J
  8. Palamà IE, Cortese B, D’Amone S, Gigli G. mRNA delivery using non-viral PCL nanoparticles. Biomaterials Science, 2015, vol. 3; p. 144-151, ISSN: 2047-4830, doi: 10.1039/C4BM00242C
  9. Palamà IE, Cortese B, D’Amone S, Gigli G. Gene therapy with non-viral PCL nanoparticles. Therapeutic Delivery, 2015, vol. 6; p. 769-771, ISSN: 2041-5990, doi: 10.4155/TDE.15.41
  10. Pagani F, Paolicelli RC, Murana E, Cortese B, Di Angelantonio S, Zurolo E, Guiducci E, Ferreira TA, Garofalo S, Catalano M, D’Alessandro G, Porzia A, Peruzzi G, Mainiero F, Limatola C, Gross CT, Ragozzino D. Defective microglial development in the hippocampus of CX3CR1 deficient mice. Frontiers in Cellular Neuroscience, 2015, vol. 9; p. 111-, ISSN: 1662-5102, doi: 10.3389/fncel.2015.00111
  11. Palamà IE, Arcadio V, Cortese B, D’Amone S, Gigli G. Dexamethasone delivery with coated calcium carbonate microcubes for sustained growth of osteoblasts. Rendiconti Lincei, Scienze Fisiche e Naturali, 2015, vol. 26; p. 239-244, ISSN: 2037-4631, doi: 10.1007/s12210-015-0430-5
  12. Palamà IE, Di Maria F, D’Amone S, Barbarella G, Gigli G. Biocompatible and biodegradable fluorescent microfibers physiologically secreted by live cells upon spontaneous uptake of thiophene fluorophore. Journal of Materials Chemistry B, 2015, 3 (1), 151- 158.
  13. Cortese B, Caschera D, Federici F, Ingo GM, Gigli G. Superhydrophobic Fabrics For Oil/Water Separation through a diamond like carbon (DLC) Coating. Journal of Materials Chemistry A, 2014, vol. 2; p. 6781-6789, ISSN: 2050-7496, doi: 10.1039/C4TA00450G
  14. Cortese B., Palamà IE, D’Amone S, Gigli G. Influence of electrotaxis on cell behaviour. Integrative Biology, 2014, vol. 6; p. 817-830, ISSN: 1757-9708, doi: 10.1039/C4IB00142G
  15. Palamà IE, D’Amone S, Biasiucci M, Gigli G, Cortese B. Bioinspired Design of a Photoresponsive Superhydrophobic/oleophilic surface with Underwater Superoleophobic Efficacy. Journal of Materials Chemistry A, 2014, vol. 2; p. 17666-17675, ISSN: 2050-7496, doi: 10.1039/C4TA04068F
  16. Caschera D, Mezzi A, Cerri L, De Caro T, Riccucci C, Ingo GM, Padeletti G, Biasiucci M, Gigli G, Cortese B. Effects of Plasma treatments for improving extreme wettability behaviour of cotton fabrics. Cellulose, 2014, vol. 21; p. 741-756, ISSN: 0969-0239, doi: 10.1007/s10570-013-0123-0
  17. Di Maria F, Palamà IE, Baroncini M, Barbieri A, Bizzarri R, Gigli G, Barbarella G. Live Cell Cytoplasm Staining and Selective Labeling of Intracellular Proteins by Non-toxic Cell-permeant Thiophene Fluorophores. Organic & Biomolecular Chemistry, 2014, 12: 1603-1610.
  18. Scalera F, Gervaso F, Sanosh KP, Palamà IE, Dimida S, Sannino A. Development of a novel hybrid porous scaffold for bone tissue engineering: forsterite nanopowder reinforced chitosan. Key Engineering Materials, 2014, 587: 249-254.
  19. Palamà IE, Coluccia AML, Gigli G. Uptake of Imatinib-loaded polyelectrolyte nanocomplexes by BCR-ABL+ cells: a long-acting drug delivery strategy for targeting oncoprotein activity. Nanomedicine (London), 2014, 9 (14): 2087-2098.
  20. Caschera D, Cortese B, Mezzi A, Brucale M, Ingo G M, Gigli G, Padeletti G. Ultra hydrophobic/superhydrophilic modified cotton textiles through functionalized Diamond-Like Carbon coatings for self-cleaning applications. Langmuir, 2013 vol. 29; p. 2775-2783, ISSN: 0743-7463, doi: 10.1021/la305032k
  21. Faraldi F, Cilingirogl, A, Angelini E, Riccucci C, De Caro T, Batmaz A, Mezzi A, Caschera D, Cortese B. Micro-chemical and micro-structural investigation of archaeological bronze weapons from the Ayanis fortress (lake Van, Eastern Anatolia, Turkey). Applied Physics A, Materials Science & Processing, 2013. vol. 113; p. 911-921, ISSN: 0947-8396
  22. Cortese B, Riehle M, D’Amone S, Gigli G. Influence of Variable Substrate geometry on Wettability and Cellular Responses. Journal of Colloid and Interface Science, 2013, vol. 394; p. 582-589, ISSN: 0021-9797, doi: 10.1016/j.jcis.2012.11.051.
  23. Cortese B, Caschera D, De Caro T, Ingo GM. Micro-chemical and -morphological features of heat treated plasma sprayed Zirconia-based Thermal Barrier Coatings. 2013, Thin Solid Films, vol. 549; p. 321-329, ISSN: 0040-6090
  24. Cortese B, Caschera D, Padeletti G, Ingo G M, Gigli G. A brief review of surface functionalized cotton fabrics. Surface Innovations, 2013, vol. 1; p. 140-156, ISSN: 2050-6252, doi: 10.1680/si.13.00008
  25. Viola I, Palamà IE, Coluccia AML, Biasiucci M, Dozza B, Lucarelli E, Bettini C, Barbarella G, Gigli G. Physiological formation of fluorescent and conductive protein microfibers in live fibroblasts upon spontaneous uptake of biocompatible fluorophores. Integrative Biology, 2013, 5, 1057- 1066
  26. Palamà IE, D’Amone S, Coluccia AML, Gigli G. Micropatterned polyelectrolyte multilayer films promote alignment and myogenic differentiation of C2C12 cells in standard growth medium. Biotechnology & Bioengineering, 2013, 110 (2), 586-596.
  27. Viola I, Zacheo A, Arima V, Aricò AS, Cortese B, Manca M, Zocco A, Taurino A, Rinaldi R, Gigli G The influence of polydimethylsiloxane curing ratio on capillary pressure in microfluidic devices. Applied Surface Science, 2012, vol. 258; p. 8032-8039, ISSN: 0169-4332
  28. Cortese B, Morgan H. Controlling the Wettability of Hierarchically Structured Thermoplastics. Langmuir, 2012, vol. 28; p. 896-904, ISSN: 0743-7463, doi: 10.1021/la203741b
  29. Palamà I.E., Coluccia A.M.L., Gigli G. and Riehle M. Modulation of alignment and differentiation of skeletal myoblasts by biomimetic materials. Integrative Biology, 2012, 4, 1299-1309.
  30. Reddiconto G., Toto C., Palamà I.E., De Leo S., De Luca E, De Matteis S., Dini L., Sanapo F., Gambacorti Passerini C., Di Renzo N., Maffia M., Coluccia A.M.L. Targeting of GSK3beta promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors preserving normal stem cells., Blood, 2012, 119 (10), 2335-2345.
  31. Palamà I.E., D’Amone S., Coluccia A.M.L., Biasiucci M. and Gigli G. Cell self-patterning on uniform PDMS-surface with controlled mechanical cues. Integrative Biology, 2012, 4, 228-236 (Highlight: the paper is the 5th position of the “top ten most accessed articles” of Integrative Biology web site in the month of December 2011, http://blogs.rsc.org/ib/page/13/).
  32. Cortese B., Mowlem M. C., Morgan H. Characterisation of an Irreversible Bonding Process for COC-COC and COC-PDMS-COC Sandwich Structures and Application to Microvalves. Sensors And Actuators B, Chemicals, 2011, vol. 160; p. 1473-1480, ISSN: 0925-4005, doi: 10.1016/j.snb.2011.07.040
  33. Ogilvie R G, Sieben V J, Cortese B., Mowlem M C, Morgan H.. Chemically resistant microfluidic valves from Viton® membranes bonded to COC and PMMA. Lab on a Chip, 2011, vol. 11; p. 2455-2459, ISSN: 1473-0189, doi: 10.1039/C1LC20069K
  34. Palamà I.E., Di Maria F., Viola I., Fabiano E., Gigli G., Bettini C. and Barbarella G. Live-cell-permeant thiophene fluorophores and cell-mediated formation of fluorescent fibrils.. Journal of the American Chemical Society (JACS), 2011, 133, 17777–17785.
  35. Palamà I.E, Musarò M., Coluccia A.M.L., D’Amone S. and Gigli G. Cell uptake and validation of novel PECs for biomedical applications.. Journal of Drug Delivery, 2011, 1-7.
  36. Athanassiou A, Cingolani R, Caputo G, Cortese B., Gigli G, Nobile C, P Cozzoli D. Reversible wettability of hybrid organic/inorganic surfaces of systems upon light irradiation/storage cycles. International Journal of Nanomanufacturing, 2010, vol. 6; p. 312-323, ISSN: 1746-9392, doi: 10.1504/IJNM.2010.034793
  37. Coluccia A.M.L., De Leo S., De Luca E., Reddiconto G., Palamà I.E., Redaelli S., De Matteis S., Gambacorti-Passarini C., Dini L. and Maffia M. Deregulated Activity and Localization of Glycogen Synthase Kinase 3 beta In Chronic Myeloid Leukemia Progenitors: Role In Leukemia Maintenance and Targeted Therapy.. Blood, 2010, 21, 521.
  38. Palamà I.E., Leporatti S., De Luca E., Gambacorti-Passerini C., Di Renzo N., Maffia M., Rinaldi R., Gigli G., Cingolani R. and Coluccia A.M.L. Imatinib-Loaded polyelectrolyte microcapsules for sustained targeting of BCR-ABL+ leukemia stem cells.. Nanomedicine, 2010, 5 (3), 419-431.
  39. Palamà I.E., Coluccia A.M.L., Della Torre A., Vergaro V., Perrone E., Cingolani R., Rinaldi R. and Leporatti S. Multilayered Polyelectrolyte Capsules and Coated Colloids: Cytotoxicity and Uptake by Cancer Cells. Science of Advanced Materials, 2010, 2, 1-9.
  40. Blasi L., Argentiere S., Morello G., Palamà I.E., Barbarella G., Cingolani R, Gigli G. Uptake and distribution of labeled antibodies into pH-sensitive microgels. Acta Biomaterials, 2010, 6, 2148-2156
  41. Cortese B., Gigli G, Riehle M. Mechanical Gradient Cues for Guided Cell Motility and Control of Cell Behaviour on uniform substrates. Advanced Funcional Materials, (2009), vol. 19; p. 2961-2968, ISSN: 1616-301X, doi: 10.1002/adfm.200900918
  42. Cortese B., Piliego C, Viola I, D’Amone S, Cingolani R, Gigli G. Engineering transfer of micro and nanometer scale features by surface energy modification. Langmiur, 2009. vol. 25; p. 7025-7031, ISSN: 0743-7463, doi: 10.1021/la900248j
  43. Caputo G, Cortese B., Nobile C, Salerno M, Cingolani R, Gigli G, Cozzoli PD, Athanassiou. A Reversibly Light-Switchable Wettability of Hybrid Organic/Inorganic Surfaces With Dual Micro-/Nanoscale Roughness. Advanced Functional Materials, 2009. vol. 19; p. 1149-1157, ISSN: 1616-301X, doi: 10.1002/adfm.200800909
  44. Cortese B., Gigli G, Riehle M. Mechanical guidance cues for control of cell motility and determination of traction forces. Biomaterialien, 2009, vol. 10, ISSN: 1616-0177
  45. Cortese B., Riehle M, D’Amone S, Gigli G. Advances in micro-fabrication: from 2D to 3D PDMS scaffolds for tissue engineering applications. European Cells & Materials, 2009, vol. 18; p. 55-, ISSN: 1473-2262
  46. Cortese B., D’Amone S, Manca M, Viola I, Cingolani R, G. Gigli. Superhydrophobicity due to the hierarchical scale roughness of PDMS surfaces. Langmuir, 2008, vol. 24; p. 2712-2718, ISSN: 0743-7463, doi: 10.1021/la702764x
  47. Manca M, Cortese B., Viola I, Arico AS, Cingolani R, G. Gigli. Influence of chemistry and topology effects on superhydrophobic CF4-plasma-treated poly(dimethylsiloxane) (PDMS). Langmuir, 2008, vol. 24; p. 1833-1843, ISSN: 0743-7463
  48. Cortese B., Riehle M, Cingolani R, Gigli G. Cells response sensing durotaxis by varying mechanical rigidity. European cells & Materials, 2008, vol. 16; p. 44-44, ISSN: 1473-2262
  49. Piliego C, Mazzeo M, Cortese B., Cingolani R, G. Gigli. Organic light emitting diodes with highly conductive micropatterned polymer anodes. Organic Electronics, 2008, vol. 9; p. 401-406, ISSN: 1566-1199, doi: 10.1016/j.orgel.2007.12.007
  50. Viola I., Pisignano D., D’Amone S., Cingolani R. and Gigli G. In-situ monitoring of viscoelastic liquid in a microfluidic enviroment.; Synthetic Metals, 2005.
  51. Rizzo A., Mazzeo M., Palumbo M., Lerario G., D’Amone S., Cingolani R., and Gigli G. Hybrid Light Emitting Diodes by ?-CP Double Transfer of Colloidal Semiconductor CdSe/ZnS Quantum Dots on Organic Layers., Advanced Materials, 2008.
  52. Viola I., Mazzeo M, Passabì A., D’Amone S., Cingolani R. and Gigli G. Organic Light Emitting Pixel Arrays by Supra-molecular Self-organization,; Proc. SPIE, 2005, vol. 5838: 29-37, Nanotechnology II.
  53. Viola I., Mazzeo M., Passabì A., D’Amone S., Cingolani R. and Gigli G. Positive/Negative Arrays of Organic Light-Emitting Diodes by a Surface-Tension-Driven Approach, Advanced Materials, 2005, 17(24): 2935-2939.
  54. Pisignano D., D’Amone S., Gigli G. and Cingolani R. Rigid organic molds for nanoimprinting lithography by replica molding of high glass transition temperature polymers, Journal of Vacum Science and Technology, 2004, B 22 (4): 1759-1763.

Book Chapter

Strategies and applications for incorporating physical and chemical modifications for functional Cellulose based materials. Barbara Cortese, Ilaria Elena Palamà, Stefania D’Amone, and Giuseppe Gigli. Cellulose and Cellulose Derivatives: Synthesis, Modification, Nanostructure and Applications. HAUPPAUGE NY 11788-3619: Nova Science Publishers, Inc., 2015 – ISBN: 978-1-63483-571-8, Chapter 2: 35 – 65  (Invited chapter).

Mechanical guidance of cell migration. Ilaria Elena Palamà, Stefania D’Amone, Barbara Cortese. Nanomaterials and Regenerative Medicine. IAPC Publishing, Zagreb, Croatia, 2016 – ISBN: 978-953-56942-3-6, Chapter 22: 563 – 580 (Invited chapter)

Patent

Cancer Therapy with Silver Nanoparticles. I.E. Palamà, M. Pollini, F. Paladini, G. Accorsi, A. Sannino and G. Gigli. US 4182.3000. 2013 and WO 3000. 2014.

Abstract: A novel approach in cancer therapy based on the cytotoxic effect of silver nanoparticles on cancer cells, without any deleterious effect on normal cells, has been developed.

Projects

My First AIRC Grant – Role of Electro/Mechanical cues in the control and guidance of Glioma Progression (MFAG)  2015 n. 16803 (2015-2018)_ Principal Investigator: Barbara Cortese

Latest News

  • Loretta del Mercato, si aggiudica l’ERC STARTING GRANT 2017

    Loretta del Mercato, si aggiudica  l’ERC STARTING GRANT 2017

    uno dei bandi più competitivi a livello europeo.

    Lecce, 6 settembre 2017 

    Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

    (more…)
  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

Biosensors & Bioelectronics

At NANOTEC Institute, several research activities are in progress concerning the optimization of a wide range of biosensors able to respond, alone or integrated in multifunctional sensing platform, to specific needs of several biological applications. On one side, we employ different biorecognition elements (antibodies, aptamers or molecular imprinted polymers) to achieve specificity. On the other, we exploit various transduction methods ranging from optical to electrical and mechanical ones in order to miniaturize the assay, reduce the cost and/or increase the sensitivity. Moreover, our studies investigate also the use of biomaterials for electronics applications. More in detail:

A panel which summarizes the different transduction strategies applied to biorecognition at NANOTEC

Biorecognition elements for sensor specificity

Many biological events are closely associated with the specific binding between biomolecules that complement each other in shape, size, charge and chemical functionality, and self-organize with nanoscale dimension at an interface (i.e., lipid assemblies, proteins, viruses). To attain high specificity and efficiency, biosensors exploit molecular recognition such as DNA base pairing or antigen-antibody reactions but we also employ aptamers and molecular imprinted polymers as emerging molecular probes. However, achieving rapid and efficient specific molecular interaction often depends on immobilization of receptors to solid surfaces with appropriate surface density, preserving the functional conformation and optimizing the presentation of the binding fragments towards the target analyte. Moreover, the ability to bind/release a molecule of interest in response to an external stimulus (i.e., temperature, pH, irradiation), has a practical impact in the field of bioseparations (purification of proteins, enzymes, pharmaceuticals) and drug delivery. In this respect, in situ analytic techniques able to determine the absolute orientation and conformation of bio- and biomimetic molecules at the interfaces are of paramount relevance. Furthermore, dynamically probing the active sites during the binding/releasing event would provide a molecular-level understanding of the receptor-analyte interaction, and eventually shed light on how the performance of biological processes in living organisms depends on the biomolecular interfacial architectures. Sum-frequency generation vibrational spectroscopy (SFG-VS) allows achieving the conformational structure and orientation distribution of biomimetic and bio- molecules at interfaces, in the working environment for chemical and biochemical sensing. As a second-order nonlinear optical processes, SFG-VS has been proven to be a versatile tool for non-invasive probing of any interface accessible by light, with intrinsic surface specificity, chemical selectivity and sub-monolayer sensitivity. Being electric-dipole forbidden in centrosymmetric bulk media but allowed at interfaces where inversion symmetry is naturally broken, SFG is highly interface-specific. SFG is a process in which two input laser beams at VIS and IR frequencies interact in a medium and generate an output beam at frequency ω_SFG=ω_VIS+ω_IR. When ω_VIS (ω_IR) and/or ω_SFG are tuned over resonances, SFG is resonantly enhanced thus yielding surface spectroscopic information. For molecular systems, vibrational spectroscopy is often more selective, since it permits identification of molecular species and provides information about their functional groups. Therefore SFG-VS, where the input beam ω_IR is scanned over vibrational resonances, has been largely exploited as surface-specific analytical probe for molecules at interfaces. SFG-VS is sensitive to the average polar orientation of each moiety and therefore to the overall molecular conformation. As a coherent process, the output beam is highly directional, allowing for in situ non-invasive remote sensing of the interface.

(Left) SFG-VS experiments are carried out at the solid-gas and liquid-gas interfaces, where surface-bound receptors are exposed to different analytes. (Right) Resonant enhancement and polarization dependence allow to deduce quantitatively conformational information on the receptors and assess the orientation of the analytes upon complexation.

Optical read-out: Sum-frequency generation vibrational spectroscopy (SFG-VS) and plasmonics

Optical sensor technology offers significant opportunities in the field of medical research and clinical diagnostics, spanning from colorimetric and fluorescent assays to more advanced approaches particularly suitable for the detection of a few molecules in highly-diluted solutions. At CNR-NANOTEC, several methods are under investigation. For example, a colorimetric “point-of-care” device was optimized exploiting electrochromism for the detection of ions in biological fluids. For few molecules detection, we are then working on label-free plasmonic biosensors based on metallic nanostructures and metamaterials. To detect lower molecular weight (<500 Da) biomolecules in highly-diluted solutions, we are investigating a hyperbolic metamaterial (HMM)-based plasmonic biosensor platform, which can support highly confined bulk plasmon guided modes in a wide wavelength range, from visible to near infrared. Hyperbolic metamaterials are perhaps the most unusual electromagnetic metamaterials, featuring hyperbolic (or indefinite) dispersion because one of their principal components has the opposite sign to the other two. Our HMM sensor device shows many highly sensitive resonant modes with a maximum sensitivity of 30,000 nm/RIU and a maximum figure of merit of 590 at near IR wavelength. In collaboration with CNR-IMM, we have also recently optimized colloidal nano-lithography as a cheap approach to fabricate planar distributions of plasmonic nanostructures with tailored optical functionalities.

Mechanical read-out: QCM and SAW

Another trasduction mechanism under investigation at CNR-NANOTEC is based on a mechanical approach. If opportunely functionalized, a quartz crystal microbalance (QCM) interacts with analytes in solution to estimate the concentration or can be used for cell studies. In our labs, we have employed QCM to study peptide-antibody interactions to allow detection of new biomarkers for early diagnosis of aggressive forms of cancer. Another application was in the field of ophthalmology to search for innovative coatings to improve contact lens performances and produce biofouling surfaces. Recently QCM was used to investigate cancer cell-drug interactions and to probe aptamer-toxin interactions in the perspective of developing biosensors for monitoring food quality. To further improve the sensitivity in mass detection, we are also working on Surface Acoustic Wave (SAW) technology and we recently optimized both delay lines and resonators.

Electrical read-out: E.I.S. and MR biosensors

Tailoring low cost, portable, easy handled devices for simple and rapid assays is a major goal for current technology research. In this respect, an electrical read-out can provide advantages. In our labs, we optimized electrochemical impedance spectroscopy (EIS) based biosensors consisting of couples of interdigitated electrodes made of gold on a glass substrate integrated with a microfluidic module for the automatic handle and delivery of solutions and samples to the sensing areas of the device. This EIS platform has been used in Lecce for diagnostics, food control, environmental monitoring and cell studies.

Recently, in Bari, a label-free impedance device was also optimized for virus early detection in apparently asimptomatic plants at attomolar concentration in collaboration with the CNR IPSP – Istituto per la Protezione Sostenibile delle Piante, UoS Bari. Specifically, Tomato the mosaic virus (ToMV) and the Turnip yellow mosaic virus (TyMV) were analyzed and the different virus charges have been found to regulate the impedance response and the electrochemical interaction with a textured surface, enabling selectiveness and quantification.

In this frame, properly functionalized nanostructures can act as high sensitive recognition element due to the high surface to volume ratio. As a different strategy, in our labs, in collaboration with Technion Institute in Haifa (Israel), functionalized silicon nanowires arrays (SiNWs) were embedded on interdigitated electrodes (IDEs) for TFT devices responding to low Volatile Organic Compounds (VOCs) concentration produced by human breath when affected by gastric cancer for a novel non invasive cancer diagnostic technique.

At NANOTEC we are also investigating magnetoresistance sensors as transducers since they promise excellent sensitivity in the detection of biomolecules labeled by magnetic particles. A new H2020 project will exploit this technology for achieving early detection of neurodegenerative diseases (Alzheimer and Parkinson).

(top) T.E.M. images of Tomato Mosaic and Turnip Yellow Mosaic virsuses (center) Schetch of the Droplet-on-high hydropobic support device structure for label free recognition and quantification of viruses via E.I.S. measurements. (bottom). Recent experimental results evidencing the feasibility of virus recognition and quantification (right)

Plasma processing of materials for sensing 

Plasma processing can be used to modify the surface properties of materials for sensing. Plasma assisted functionalization of surfaces can be performed in order to introduce nitrogen and oxygen containing groups other than micro-nanopatterned surfaces and promote further immobilization or analysis of molecules

Bioelectronics

In bio-molecules, like amino-acid derivatives, proteins etc.. the water bounding is of fundamental importance. This feature is generally encountered in living cells, where water binds to the structure and fluctuates from an ordered to a disordered structure. In this respect melanin and melanin-like materials have displayed a peculiar hydration dependent modification of their properties and specifically of the electrical one, leading to consider melanin as an electret able to store water derived charges.

Even if such behavior was a well known feature disclosed in the past, only recently our group was able to demonstrate that it is possible not only to relate the amount of the stored charge to the magnitude of an applied signal (e.g. a continuous voltage) but also that the transmitted information is not erasable and can be stored for a long time. Moreover, depending from the hydration state, the origin of the storage is switching from an electron/hole charge trapping to a polarization effect, the latter regulated by the residual water ions. A recently afforded fundamental issue concerns the kind of physicochemical interactions between water molecules and eumelanin in determining the functionalities, which possibly can hinder the development of rational strategies to fine tune the ionic-electronic conduction mechanisms, a primary goal in the design of bio-electronic devices useful for memory recovering or powering.

As valid alternative to melanins-based biological system, Polydopamine (pDA) constitutes an attractive platform due to the easy deposition by dip-coating, the eumelanin-like properties and the possibility to tune its properties by binding to proper functionalities. As an example, our group thanks to the collaboration with the Prof. M. d’Ischia’s group (Chemistry Dpt at the University of Naples) was able to demonstrate the feasibility of chemical doping and tuning of the electrical transport when pDA is co-polymerized with electron-donating systems. Inspired by the powerful photosensitizing properties of the red hair pigments pheomelanins, a photoresponsive cysteine-containing polydopamine obtained via oxidative copolymerization of dopamine (DA) and 5-S-cysteinyldopamine (CDA) in variable ratios was produced and tested. In particular, the obtained copolymer replicates in a certain extent, the structure of neuromelanin. The use of the p(DA/CDA) copolymer constituted in this case a first example of technological exploitation of photoactive, red hair-inspired biomaterials as soft enhancement layer for a bio-friendly bio- device with a chemically tunable response to visible light. Interestingly, respect to pDA, the p(DA/CDA) copolymers displayed an interesting properties binding water in a fashion similar to those of biological materials and a marked photoimpedance response to light stimuli.

Recent findings on the tunablity of the electrical/optical properties of polydopamine including the doping modification (top) and enhancement of the optical response when passing from the black (eumelanin) to the reddish (pheomelanin) one after the addition of CDA

Facilities & Labs

Characterization Lab @ Lecce
Bio Lab @ Lecce
NanoFab Lab @ Lecce
Micro/nano fabrication @ Rende
Optoelectronic Characterization Labs@ URT Bari
Bio Lab @ URT Bari
Plasma Technologies Lab @ URT Bari
Chemical-Structural Characterization Lab @ URT Bari

People

Valentina_ArimaValentina

Arima

CNR Researcher

Monica_BiancoMonica

Bianco

CNR PostDoc

Elisabetta

Primiceri

CNR PostDoc

Laura_BlasiLaura

Blasi

CNR Researcher

Alessandra_ZizzariAlessandra

Zizzari

Associate PhD Student

Pietro-FaviaPietro

Favia

Associate Professor

Eloisa_SardellaEloisa

Sardella

CNR Researcher

Marianna_AmbricoMarianna

Ambrico

CNR Researcher

PaoloFrancesco_AmbricoPaolo Francesco

Ambrico

CNR Researcher

Pasquale_PagliusiPasquale

Pagliusi

Associate Professor

Giuseppe-StrangiGiuseppe

Strangi

CNR Researcher

Giuseppe_MaruccioGiuseppe

Maruccio

Associate Professor

AnnaGrazia_MonteduroAnna Grazia

Monteduro

Associate PostDoc

Serena_ChiriacòMaria Serena

Chiriacò

CNR PostDoc

Gabriella_CipparroneGabriella

Cipparrone

Associate Professor

scolesGiacinto

Scoles

Emeritus Professor

Publications

  1. M. Bianco, A. Sonato, A. De Girolamo, M. Pascale, F. Romanato, R. Rinaldi, V. Arima An aptamer-based SPR-polarization platform for high sensitive OTA detection Sensors & Actuators: B. Chemical 314-320 (2017) ISSN: 0925-4005; doi: 10.1016/j.snb.2016.10.056
  2. A. Aprile, F. Ciuchi, R. Pinalli, E. Dalcanale, P. Pagliusi, Probing Molecular Recognition at the Solid-Gas Interface by Sum-Frequency Vibrational Spectroscopy, Journal of Physical Chemistry Letters, 7, 3022-3026, (2016) ISSN 1948-7185; doi: 10.1021/acs.jpclett.6b01300
  3. A. Aprile, P. Pagliusi, F. Ciuchi, R. Pinalli, E. Dalcanale, Probing cavitand-organosilane hybrid bilayers via sum frequency vibrational spectroscopy, Langmuir 30, 12843 (2014) ISSN: 0743-7463; doi: 10.1021/la503150z.
  4. S. R. Cicco, M.Ambrico, P.F.Ambrico, M.Mastropasqua Talamo, A.Cardone,T.Ligonzo, R. DiMundo, C. Giannini, T. Sibillano, G.M. Farinola, P.Manini,A.Napolitano, V. Criscuolo, M. D’Ischia A water-soluble eumelanin polymer with typical polyelectrolyte behaviour by triethyleneglycol N-functionalization, Journal of Material Chemistry, C 3, 2810-2816 (2015) ISSN: 2050-7526; doi: 10.1039/c4tc01997k
  5. M. Ambrico, P.F. Ambrico, A. Cardone, S.R. Cicco, F. Palumbo, T. Ligonzo, R. di Mundo, V. Petta, V. Augelli, P. Favia and G. M. Farinola Melanin-like polymer layered on a nanotextured silicon surface for a hybrid biomimetic interface, Journal of Material Chemistry C, 2,573, (2014) ISSN 2050-7534; doi: 10.1039/c3tc31327a
  6. M. Ambrico, N.F. Della Vecchia, P.F. Ambrico, A. Cardone, S.R.Cicco, T. Ligonzo, R.Avolio and A. Napolitano, A Photoresponsive Red-Hair-Inspired Polydopamine Based Copolymer for Hybrid Photocapacitive Sensors, Advanced Functional Materials, 24,7161-7172, (2014), ISSN: 1616-3028; doi: 10.1002/adfm.201401377
  7. N. F. Della Vecchia, R. Marega, M. Ambrico, M. Iacomino, R. Micillo, A. Napolitano, D. Bonifazi  and M. d’Ischia Tailoring melanins for bioelectronics: polycysteinyldopamine as an ion conducting redox-responsive polydopamine variant for pro-oxidant thin films, Journal of Material Chemistry C, 3,6525-6531,(2015) ISSN 2050-7534; doi: 10.1039/c5tc00672d
  8. M. Ambrico (Lead Guest Editor) Special issue: Melanin, a long lasting history bridging natural pigments and organic bioelectronics, Polymer International, 65,11 (2016) ISSN: 1097-0126; doi: 10.1002/pi.5239
  9. G. Da Ponte, E. Sardella, F. Fanelli, S. Paulussen, P. Favia. Atmospheric pressure plasma deposition of poly lactic acid-like coatings with embedded elastin. Plasma Processes and Polymers 11-4, 342-352 (2014) ISSN: 1612-8850; doi: 10.1002/ppap.201300130
  10. M. Bianco, V. Guarino, G. Maruccio, G. Galli, E. Martinelli, G. Montani, R. Rinaldi and V. Arima Non-Biofouling Fluorinated Block Copolymer Coatings for Contact Lenses Sci. Adv. Mater. 7, 1387-1394 (2015). ISSN: 1947-2935; doi: 10.1166/sam.2015.2056
  11. Z. Ameer, E. Primiceri, F. De Feo, M. S. Chiriacò, A. G. Monteduro, G. Maruccio and R. Rinaldi, DNA sensors with impedimetric and magnetoresistive transduction – A comparison study, Proceedings of 2014 11th International Bhurban Conference on Applied Sciences and Technology, IBCAST 2014 65-68 (2014). ISSN: 2151-1403; doi: 10.1109/IBCAST.2014.6778122
  12. S. Chiriacò, F. de Feo, E. Primiceri, A. G. Monteduro, G. E. de Benedetto, A. Pennetta, R. Rinaldi and G. Maruccio, Portable gliadin-immunochip for contamination control on the food production chain Talanta 142, 57-63 (2015) ISSN: 00399140; doi: 10.1016/j.talanta.2015.04.040
  13. A. Colombelli, M. G. Manera, R. Rella, S. Rizzato, E. Primiceri, A. G. Monteduro and G. Maruccio, Colloidal lithography fabrication of tunable plasmonic nanostructures, IET Conference Publications 2015, Vol. 2015. doi: 10.1049/cp.2015.0148
  14. S. Chiriacò, E. Primiceri, F. De Feo, A. Montanaro, A. G. Monteduro, A. Tinelli, M. Megha, D. Carati and G. Maruccio, Simultaneous detection of multiple lower genital tract pathogens by an impedimetric immunochip, Biosensors and Bioelectronics 79, 9-14 (2016) ISSN: 0956-566; doi: 10.1016/j.bios.2015.11.100
  15. V. De Matteis, A. Cannavale, L. Blasi, A. Quarta, G. Gigli Chromogenic device for cystic fibrosis precocious diagnosis: A “point of care” tool for sweat test Sensors and Actuators B: Chemical 225, 474–480 (2016) ISSN: 09254005; doi: 10.1016/j.snb.2015.11.080
  16. G. Palazzo , D. De Tullio, M. Magliulo , A. Mallardi , F. Intranuovo , M.Y.Mulla , P.Favia, I.V.-Lundin , L. Torsi, Detection Beyond Debye’s Length with an Electrolyte-Gated Organic Field-Effect Transistor, Adv. Mater. 27, 911–916 (2015) ISSN: 0935-9648; doi: 10.1002/adma.201403541
  17. V. Sreekanth, Y. Alapan, M. ElKabbash, U. A. Gurkan, E. Ilker, M. Hinczevski, A. De Luca and G. Strangi, Extreme sensitivity biosensing platform based on hyperbolic metamaterials Nature Materials 15 (6), 621 (2016) ISSN: 1476-1122, DOI: 10.1038/NMAT4609
  18. V. Caligiuri, R. Dhama, K. Valiyaveedu Sreekanth, G. Strangi and A. De Luca Dielectric singularity in HMM: the inversion point of coexisting anisotropies, Scientific Reports (Nature Publishing Group) 6, 20002 (2016) ISSN: 2045-2322; doi: 10.1038/srep20002
  19. V. Sreekanth, K. Hari Krishna, A. De Luca and Giuseppe Strangi Large spontaneous emission rate enhancement in grating coupled hyperbolic metamaterials Scientific Reports (Nature Publishing Group) 4, 6340 (2014) ISSN: 2045-2322; doi: 10.1038/srep06340

Other selected publications:

  1. H. Haick, M.Ambrico, T.Ligonzo and D. Cahen, Controlling Semiconductor/Metal Junction Barriers by Incomplete, Nonideal Molecular Monolayers Journal of the American Chemical Society 128, 6854-6869 (2006) ISSN: 0002-7863; doi: 10.1021/ja058224a
  2. M. Ambrico, P.F.Ambrico, A.Cardone, T.Ligonzo, S.R.Cicco, R.Di Mundo, V. Augelli, G.M. Farinola, Melanin Layer on Silicon: an Attractive Structure for a Possible Exploitation in Bio-Polymer Based Metal-Insulator-Silicon Devices, Advanced Materials, 23,3332-3336,(2011) ISSN: 0935-9648; doi: 10.1002/adma.201101358
  3. M. Ambrico, A.Cardone, P.F,Ambrico, T.Ligonzo, V.Augelli, S.R.Cicco, G.M. Farinola, M.Filannino, G. Perna and V.Capozzi. Hysteresis-type current–voltage characteristics in Au/eumelanin/ITO/glass structure: Towards melanin based memory devices, Organic Electronics 11,1809-1814, 2010 ISSN: 1566-1199; doi: 10.1016/j.orgel.2010.08.001
  4. M. Tulliani, A. Cavalieri, S. Musso, E. Sardellad, F. Geobaldo; Room temperature ammonia sensors based on zinc oxide and functionalizedgraphite and multi-walled carbon nanotubes; Sensors and Actuators B 152 (2011) 144–154 ISSN: 0925-4005; doi: 10.1016/j.snb.2010.11.057
  5. V. Sreekanth, Antonio De Luca & Giuseppe Strangi   Experimental demonstration of surface and bulk plasmon  polaritons  in  hypergratings Scientific Reports (Nature Publishing Group) 3, 03291 (2013) ISSN: 2045-2322; doi: 10.1038/srep03291
  6. M. Bianco, A. Aloisi, V. Arima, M. Capello, S. Ferri-Borgogno, F. Novelli, S. Leporatti and R. Rinaldi Quartz Crystal Microbalance with Dissipation (QCM-D) as tool to exploit antigen-antibody interactions in pancreatic ductal adenocarcinoma detection Biosensors and Bioelectronics 42, 646–652 (2013) ISSN: 0956-5663; doi: 10.1016/j.bios.2012.10.012
  7. E. Primiceri, M. S. Chiriacò, E. D’Amone, E. Urso, R. E. Ionescu, A. Rizzello, M. Maffia, R. Cingolani, R. Rinaldi and G. Maruccio, Real-time monitoring of copper ions-induced cytotoxicity by EIS cell chips, Biosens. Bioelectron. 25, 2711-2716 (2010) ISSN: 09565663; doi: 10.1016/j.bios.2010.04.032
  8. M. S. Chiriacò, E. Primiceri, E. D’Amone, R. E. Ionescu, R. Rinaldi and G. Maruccio, EIS microfluidic chips for flow immunoassay and ultrasensitive cholera toxin detection, Lab on a Chip 11, 658-663 (2011). ISSN: 1473-0197; doi: 10.1039/c0lc00409j
  9. E. Primiceri, M. S. Chiriacò, F. Dioguardi, A. G. Monteduro, E. D’Amone, R. Rinaldi, G. Giannelli and G. Maruccio, Automatic transwell assay by an EIS cell chip to monitor cell migration, Lab on a Chip 11, 4081-4086 (2011). ISSN: 1473-0197; doi: 10.1039/c1lc20540d
  10. M. S. Chiriacò, E. Primiceri, A. Montanaro, F. de Feo, L. Leone, R. Rinaldi and G. Maruccio, On-chip screening for prostate cancer: an EIS microfluidic platform for contemporary detection of free and total PSA, Analyst 138, 5404-5410 (2013). ISSN: 0003-2654; doi: 10.1039/c3an00911d

Patent

  1. V. Sreekanth, Y. Alapan, M. ElKabbash, U. A. Gurkan, E. Ilker, M. Hinczevski, A. De Luca and G. Strangi, “Extreme sensitivity biosensing platform based on hyperbolic metamaterials” Invention Disclosure and  Patent Pending (USA)

Project

  1. Safemeat: Innovazioni di processo e di prodotto per incrementare i profili di sicurezza e per diversificare la gamma di prodotti (freschi e stagionati) a base di carne suina – MIUR-PON project (2012-2014)
  2. MADIA: Magnetic Diagnostic Assay for neurodegenerative diseases – H2020, ICT-03-2016 “SSI – Smart System Integration” (2017-2020)
  3. Nano-Biotecnologie per Diagnostica e sviluppo di Terapie innovative –  Regional project APQ Ricerca Scientifica—Reti di Laboratori Pubblici di Ricerca” – (2010-2012).

Latest News

Loretta del Mercato, si aggiudica l'ERC STARTING GRANT 2017

Loretta del Mercato, si aggiudica  l'ERC STARTING GRANT 2017

uno dei bandi più competitivi a livello europeo.

Lecce, 6 settembre 2017 

Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

Su 3085 progetti presentati, 406 i progetti selezionati a cui sono stati destinati i 605 i milioni di euro di investimento. 48 le nazioni di provenienza dei ricercatori, soltanto 17 gli Italiani che condurranno le loro ricerche nel nostro paese, tra cui Loretta del Mercato, ricercatrice dell'Istituto di Nanotecnologia del Consiglio Nazionale delle Ricerche di Lecce.

Un importante riconoscimento alla ricerca nel settore della medicina di precisione condotta presso il CNR NANOTEC, un indiscusso premio al talento della giovane ricercatrice che, a 38 anni e un contratto a tempo determinato, sarà a capo del progetto "Sensing cell-cell interaction heterogeneity in 3D tumor models: towards precision medicine – INTERCELLMED".

Il progetto, il cui obiettivo è affrontare uno dei problemi più spinosi della ricerca sul cancro, ovvero la difficoltà nel trasformare i risultati delle ricerche scientifiche in applicazioni cliniche per i pazienti e che vedrà coinvolto l'Istituto tumori "Giovanni Paolo II" di Bari, si propone di sviluppare nuovi modelli in vitro 3D di tumore del pancreas, alternativi ai modelli animali, ingegnerizzati con un set di sensori nanotecnologici che consentiranno di monitorare le interazioni delle cellule tumorali con il loro micorambiente, verificare l'appropriatezza delle terapie prima della somministrazione ai pazienti oncologici e quindi prevedere la risposta dei singoli pazienti ad una o più terapie antitumorali.

La realizzazione di queste piattaforme 3D multifunzionali consentirà di superare le evidenti differenze intercorrenti tra "modelli animali" ed esseri umani fornendo dati attendibili ed in tempi più rapidi rispetto ai dati ottenuti tramite lunghi e costosi procedimenti di sperimentazione sugli animali. Le tecnologie e i modelli sviluppati saranno estesi anche ad altre forme di tumori solidi nonché impiegati per studi nell'ambito della ingegneria tissutale e della medicina rigenerativa.

Rassegna stampa e Video

Zeiss Microscopy Technology and Complete Correlative Workflow

[vc_row][vc_column][vc_column_text]

Zeiss Microscopy Technology and Complete Correlative Workflow

Lecce, Italy, 2017 Wednesday July 19th 

CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

Program - PDF

Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

[/vc_column_text][/vc_column][/vc_row]

MCS 2017

International Workshop on Micropropulsion and CubeSats

Bari, Italy, 26 - 27 June 2017

Program - MSC2017

This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

Spintronics

The remarkable trend in electronics described by the Moore law is today experiencing increasing difficulties due to fundamental limitations in the current miniaturization approach. Alternative strategies need to be developed, e.g. exploiting a bottom-up molecular approach, mesoscopic devices, additional degrees of freedom or quantum physics. In this frame, spin is likely going to play a crucial role to carry classical or quantum information. Spintronics research in Lecce addresses different fields, from nanoscale devices based on magnetic molecules or nanoparticles to magnetic multilayers and more recent activities on RF systems for hybrid spintronics. Furthermore, we also investigate novel materials (such as multiferroics and functional oxides) and perform magnetic and ferroelectric characterizations. More in detail:

NanoElectronics/Spintronics

This research was the starting point for the group, thanks to the EU project SpiDME. To interconnect the individual building blocks at the nanoscale, we employ electron beam lithography (EBL), focused ion beam or a non- conventional method based on the selective wet-etching and oxidation of an AlGaAs/GaAs quantum well structure for the simultaneous fabrication of large arrays of nanodevices. Molecules or nanoparticles are typically positioned by specific immobilization procedures exploiting suitable functional end-groups. Charge and spin transport studies are carried out within superconducting magnets up to 10.5T and down to 10 mK.

Transport studies in large scale nanojunction arrays with Bisferrocene-nanoparticle hybrids [S. Karmakar et al., Nanoscale 2012, 4, 2311-2316, http://dx.doi.org/10.1039/C2NR11195K].
Transport studies in large scale nanojunction arrays with Bisferrocene-nanoparticle hybrids [S. Karmakar et al., Nanoscale 2012, 4, 2311-2316, http://dx.doi.org/10.1039/C2NR11195K].

Nanomagnetism

Nanomagnetism in magnetic materials and nanoparticles is investigated by vibrating sample magnetometry and a.c. susceptibility. Beyond hysteresis, both zero-field cooled and field cooled curves are typically acquired to evaluate the blocking temperature.

(left) Magnetic hysteresis curves and (right) zero-field cooled and field cooled curves for Fe3O4 nanoparticles.
(left) Magnetic hysteresis curves and (right) zero-field cooled and field cooled curves for Fe3O4 nanoparticles.

Magnetic Multilayers

Multilayer structures are the basis for giant or tunneling magnetoresistance devices. Our research focuses on the integration of further layers including nanoparticles, magnetic molecules, multiferroics or superconducting films. On the technological side, the target is to achieve a large magnetoresistance, which is useful for further applications such as in biosensors.

TMR junctions with nanocrystal superlattice films and their TMR and magnetic response [I. C. Lekshmi et al., ACS Nano 2011, 5, 1731-1738, Doi: 10.1021/nn102301y].
TMR junctions with nanocrystal superlattice films and their TMR and magnetic response [I. C. Lekshmi et al., ACS Nano 2011, 5, 1731-1738, Doi: 10.1021/nn102301y].

RF systems for hybrid spintronics

Recently, we started to investigate 3D microwave cavities and SAW devices for their integration in hybrid spintronic architectures where photons and phonons are coupled to the magnetic degree of freedom.

Multiferroics and Functional Oxides

Here we investigate high-k materials for gate stack technology in logic and memory devices and multiferroic materials for implementing novel operational concepts in spintronics exploting magnetoelectric coupling. Structural, morphological and dielectrical characterizations are typically carried out, while ferroelectric and multiferroic properties are investigated by means of PFM, KPFM, Dielectric and Ferroelectric (PUND) measurements.

.

Dielectric investigation of high-k YCTO thin films [A. G. Monteduro et al., J.Mat.Chem.C 2016, 4, 1080-1087, http://dx.doi.org/10.1039/C5TC03189C].
Dielectric investigation of high-k YCTO thin films [A. G. Monteduro et al., J.Mat.Chem.C 2016, 4, 1080-1087, http://dx.doi.org/10.1039/C5TC03189C].

Facilities & Labs

Lab di Caratterizzazione @ Lecce

NanoFab Lab  @ Lecce

People

Giuseppe_MaruccioGiuseppe

Maruccio

Associate Professor

AnnaGrazia_MonteduroAnna Grazia

Monteduro

Associate PostDoc

SilviaRizzatoSilvia

Rizzato

Associate PhD Student

angeloLeoAngelo

Leo

Associate PhD Student

Publications

  1. A. G. Monteduro, Z. Ameer, M. Martino, A. P. Caricato, V. Tasco, I. C. Lekshmi, R. Rinaldi, A. Hazarika, D. Choudhury, D. D. Sarma and G. Maruccio, Dielectric investigation of high-k yttrium copper titanate thin films, Journal of Materials Chemistry C 2016, Vol., p., issn.  2050-7526, Doi: 10.1039/C5TC03189C.
  2. A. G. Monteduro, Z. Ameer, S. Rizzato, M. Martino, A. P. Caricato, V. Tasco, I. C. Lekshmi, A. Hazarika, D. Choudhury, D. D. Sarma and G. Maruccio, Investigation of high- k yttrium copper titanate thin films as alternative gate dielectrics, Journal of Physics D: Applied Physics 2016, Vol.   49, p.  405303, issn.  0022-3727, Doi: 10.1088/0022-3727/49/40/405303
  3. A. Colombelli, M. G. Manera, R. Rella, S. Rizzato, E. Primiceri, A. G. Monteduro and G. Maruccio, Colloidal lithography fabrication of tunable plasmonic nanostructures, IET Conference Publications2015, Vol.   2015, p., issn., Doi: 10.1049/cp.2015.0148.Other Selected Publications
  4. of Advanced Materials 2013, Vol.   5, p.  2015-2020, issn.  1947-2935, Doi:  10.1166/sam.2013.1702.

Patents

Maruccio, E. Primiceri, P. Marzo, V. Arima, R. Krahne, T. Pellegrino, A. Della Torre, F. Calabi, R. Cingolani, R. Rinaldi, Electrical transduction method and device for the detection of biorecognition events in biomolecular interaction processes for genome/proteome analysis, Italian patent number TO2007A000341 (15-5-2007), International Publication number WO 2008/139421 (20-11-2008).

Project

  1. MADIA: Magnetic Diagnostic Assay for neurodegenerative diseases, UE-H2020-ICT, Work programme topic addressed: ICT-03-2016 “SSI – Smart System Integration” (2017-2020).
  2. MEMO: Imaging MEtallorganic MOlecules: Scanning tunneling spectroscopy and many-body theory, MIUR-PRIN Project (2014-2016)
  3. MolArNet: Molecular Architectures for QCA-inspired  Boolean Networks, FP7-ICT-CP, Grant No. 318516, (2012-2016) Partners: Alma Mater Studiorum-Università di Bologna, Université de Strasbourg, Technische Universitaet Dresden, Trinity College Dublin – School Of Physics, Stmicroelectronics Srl.
  4. Molecular nanomagnets on metallic and magnetic surfaces for applications in molecular spintronics MIUR-FIRB Project (2011-2014)
  5. Spintronic devices for mass-scale electronic: MAE-India, High-relevance project for scientific and technological co-operation between Italy and India (2008-2010).
  6. SpiDME: Spintronic Devices for Molecular Electronics, UE-FP6-NEST-STREP Grant Agreement No. 029002, (2006-2010)  Partners:  University of Hamburg – Institute for Applied Physics; University of Nijmegen – Institute for Molecules and Materials; Trinity College Dublin – School of Physics.

Latest News

Loretta del Mercato, si aggiudica l'ERC STARTING GRANT 2017

Loretta del Mercato, si aggiudica  l'ERC STARTING GRANT 2017

uno dei bandi più competitivi a livello europeo.

Lecce, 6 settembre 2017 

Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

Su 3085 progetti presentati, 406 i progetti selezionati a cui sono stati destinati i 605 i milioni di euro di investimento. 48 le nazioni di provenienza dei ricercatori, soltanto 17 gli Italiani che condurranno le loro ricerche nel nostro paese, tra cui Loretta del Mercato, ricercatrice dell'Istituto di Nanotecnologia del Consiglio Nazionale delle Ricerche di Lecce.

Un importante riconoscimento alla ricerca nel settore della medicina di precisione condotta presso il CNR NANOTEC, un indiscusso premio al talento della giovane ricercatrice che, a 38 anni e un contratto a tempo determinato, sarà a capo del progetto "Sensing cell-cell interaction heterogeneity in 3D tumor models: towards precision medicine – INTERCELLMED".

Il progetto, il cui obiettivo è affrontare uno dei problemi più spinosi della ricerca sul cancro, ovvero la difficoltà nel trasformare i risultati delle ricerche scientifiche in applicazioni cliniche per i pazienti e che vedrà coinvolto l'Istituto tumori "Giovanni Paolo II" di Bari, si propone di sviluppare nuovi modelli in vitro 3D di tumore del pancreas, alternativi ai modelli animali, ingegnerizzati con un set di sensori nanotecnologici che consentiranno di monitorare le interazioni delle cellule tumorali con il loro micorambiente, verificare l'appropriatezza delle terapie prima della somministrazione ai pazienti oncologici e quindi prevedere la risposta dei singoli pazienti ad una o più terapie antitumorali.

La realizzazione di queste piattaforme 3D multifunzionali consentirà di superare le evidenti differenze intercorrenti tra "modelli animali" ed esseri umani fornendo dati attendibili ed in tempi più rapidi rispetto ai dati ottenuti tramite lunghi e costosi procedimenti di sperimentazione sugli animali. Le tecnologie e i modelli sviluppati saranno estesi anche ad altre forme di tumori solidi nonché impiegati per studi nell'ambito della ingegneria tissutale e della medicina rigenerativa.

Rassegna stampa e Video

Zeiss Microscopy Technology and Complete Correlative Workflow

[vc_row][vc_column][vc_column_text]

Zeiss Microscopy Technology and Complete Correlative Workflow

Lecce, Italy, 2017 Wednesday July 19th 

CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

Program - PDF

Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

[/vc_column_text][/vc_column][/vc_row]

MCS 2017

International Workshop on Micropropulsion and CubeSats

Bari, Italy, 26 - 27 June 2017

Program - MSC2017

This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

Nano-Biotechnology

Nano-biotechnology in Lecce aims at the development of nanotechnology-based tools for biomedical applications. The bottom-up and top-down approaches, typical of nanotechnology, applied to biology and biochemistry lead to the development of nanostructured materials and devices to improve several fields of current biomedical research like Biomolecular Delivery, advanced and high resolution Imaging and Regenerative Medicine. Nanotechnology investigation tools of materials and surfaces applied to biology increase the basic knowledge ofself-assembly of biomolecules and of cellular mechanisms (Cell Biology). In the view of providing “point-of-care” diagnostic toolsand state-of-the–art approaches towards personalized medicine,microscale devicesare developedas described in the section Lab on Chip.

Biomolecular Delivery

The major goal in designing nanosystems as drug delivery vectors is to control the release of pharmacologically active agents and to achieve the site-specific action of drugs at a therapeutically optimal rate and dosage regimen…

Cell biology

The research activities of this area at the cross-roads of materials science, nanotechnology and cell biology, primarily focusing on how newly-discovered materials and interfacial processes can be developed and used for specific applications…

Imaging

At NANOTEC several high resolution techniques are available for fine imaging of biomolecules, living cells and tissue. Mainly we focus on engineering of high-resolution molecular and semiconductor-based tools for fine fluorescence imaging…

Regenerative medicine

Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating cells, tissues or organs to restore or establish normal function…

Lab on chip (LOC)

The Lab on a Chip (LOC) family is wide and multifaced due to the large number of possible applications ranging from the biomedical to the agrifood and environmental fields….

immagine_biosensingbioelectronics-copy

Biosensors & Bioelectronics

At NANOTEC Institute, several research activities are in progress concerning the optimization of a wide range of biosensors able to respond, alone or integrated…

Latest News

  • Loretta del Mercato, si aggiudica l’ERC STARTING GRANT 2017

    Loretta del Mercato, si aggiudica  l’ERC STARTING GRANT 2017

    uno dei bandi più competitivi a livello europeo.

    Lecce, 6 settembre 2017 

    Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

    (more…)
  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

Photonics & Optoelectronics

The investigation of frontier physics mainly related to the interactions and coupling of light with matter both from a macroscopic point of view as well as at the single particle level. Collective coherent phenomena of condensates of Bose Einstein are studied in semiconductor materials exploiting quasiparticles generated by the strong coupling between light and excited states of matter to unravel a rich phenomenology of quantum fluids under superfluid or supersonic regimes, exploring the dynamics of vortex states, optically driven non-equilibrium condensates and the expanding or trapping of quantum gases. Other fields of interest are correlation of quantum states, and highly confined plasmon-polariton fields. Inorganic semiconductors and organic materials are investigated from a fundamental point of view as well as for new applicative concepts, like all-optical transistors, switches and logical gates.

Quantum Fluid Dynamics

Polaritons are light-matter particles formed by a strong interaction between the electronic excited states in a semiconductor and the light field of a microcavity. Recently…

Polaritonics

The aim of this line is to fabricate new structures and explore new materials for the study of polariton quantum flow dynamics and their use for optical devices,…

Metamaterials

Metamaterials (MMs) constitute the frontier in material science technology. Unlike classic natural materials, MMs optical properties can be easily tailored as desired by…

OrganicRandomLaser

Organic Random Lasers

Plasmons are electromagnetic modes associated with the coherent excitation by photons of the free electrons at the interface between a metal and a dielectric material…

Immagine7360x194-orangepeel

Plasmonics

Plasmons are electromagnetic modes associated with the coherent excitation by photons of the free electrons at the interface between a metal and a dielectric material…

Latest News

  • Loretta del Mercato, si aggiudica l’ERC STARTING GRANT 2017

    Loretta del Mercato, si aggiudica  l’ERC STARTING GRANT 2017

    uno dei bandi più competitivi a livello europeo.

    Lecce, 6 settembre 2017 

    Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

    (more…)
  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

Advanced Devices

Starting from the different class of advanced materials studied and developed in NANOTEC, the Advanced Devices area focus on the integration of these materials into functional and multifunctional structures and devices with enhanced or new properties.   Large efforts are devoted to research and technology development at the nanoscale by using both, the bottom-up and top-down approaches, to allow (nano) structures, microarrays and components to be designed and fabricated for the realization of discrete electronic/photonic components of direct industrial and societal interest and for a wide range of applications. Devices such next generation of energy-saving light sources, low power and high speed electronics device, new generation of photovoltaic devices, spintronic devices based on single magnetic molecules/nanoparticles and on charge/spin transport, advanced sensors, catalytic devices are explored with a multidisciplinary approach and developed up to prototype level.

Photovoltaics

The recruitment of energy sources is becoming a worldwide strategic problem, because of the rapid depletion of fossil fuels from one hand, and the need of eco-compatible solutions to face the global warming…

Mechanical energy harvesters

Energy harvesters exploiting vibrational and mechanical energy sources are promising building blocks for the realization of sustainable energy systems to be employed in different application environments…

__Spintronics Entry2

Spintronics

This research was the starting point for the group, thanks to the EU project SpiDME. To interconnect the individual building blocks at the nanoscale, we employ electron beam lithography (EBL), focused…

Electroluminescent and photonic organic devices

OLEDs are devices which convert electricity into light through the process of electroluminescence. They are made by depositing an organic…

EL.PHO

The expansive growth of electronics based on inorganic, organic and hybrid materials has lead to the development of a number of significant applications, ranging from low-cost photovoltaics (OPV)…

Latest News

  • Loretta del Mercato, si aggiudica l’ERC STARTING GRANT 2017

    Loretta del Mercato, si aggiudica  l’ERC STARTING GRANT 2017

    uno dei bandi più competitivi a livello europeo.

    Lecce, 6 settembre 2017 

    Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

    (more…)
  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

Materials

NANOTEC is engaged in various aspects of materials research for advanced applications. Research activities are focused on growth and synthesis with various physical and chemical methodologies (CVD, MOCVD, MBE, PVD, PECVD, self-assembling, sol-gel, etc); based on fundamental research, we elucidate principles underpinning processing-structure-property relationships in functional materials and nanomaterials both inorganic and organic, and their hybrids and nanocomposites, with interesting electronic, magnetic, optical, mechanical or catalytic properties; we exploit those relationships to introduce new functionalities in materials science and build a basis for “predicting” new materials based on the established principles. Topics covered include III-V semiconductors, Si-based alloys, organic semiconductors, dielectrics, piezoelectrics, ferroelectrics, nanomaterials, graphene, 2D-materials, nanocomposites, colloidal nanocrystals, non-crystalline solids, self-assembled monolayers and functional surfaces. Through these efforts, NANOTEC aims to create advanced materials that contribute to society functional innovations.

Inorganic Semiconductors

Our objective here at CNR-Nanotec is the development of new semiconducting materials and nanostructures representing the foundation of more efficient, high performance, low power consumption optoelectronics…

Organic Materials

Organic materials π-conjugated with photo- and electroactive properties have a crucial role in field of organic electronics including applications such as organic solar cells (OSC), organic light emitting diodes (OLEDs)…

Colloidal Inorganic Nanocrystals

Colloidal Inorganic Nanocrystals otherwise known as ‘artificial atoms’ because the density of their electronic states, which controls many physical properties, can be regularly tuned by maneuvering the chemical composition…

Latest News

  • Loretta del Mercato, si aggiudica l’ERC STARTING GRANT 2017

    Loretta del Mercato, si aggiudica  l’ERC STARTING GRANT 2017

    uno dei bandi più competitivi a livello europeo.

    Lecce, 6 settembre 2017 

    Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

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  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

Electroluminescent and photonic organic devices

OLEDs are devices which convert electricity into light through the process of electroluminescence. They are made by depositing an organic stack of tens of nanometers between two flat electrodes.  When an external voltage is applied to the device electrons are injected from the cathode and holes from the anode. Than they form excitons in the active layer which emit photons, with an energy equal to the energy gap of the active molecules. The structures are realized by doping the transport layers with electron-acceptor or electron-donating molecules (pin structure). Owing to pin structure we are able to finely tune the device without altering the electrical performances, thus allowing to work near the thermodynamic limit (applied voltage near the energy gap of emitting layer per unit charge) and to fabricate LED embedded into an electrically active micro-cavity. The research activities are focused on the following areas:

  1. Development of hybrid electroluminescent integrated devices
  2. Development of electroluminescent organic devices for industrial applications

Development of electroluminescent hybrid integrated devices

Electroluminescence is the process of generation of light by electrical injection of opposite carriers (electrons and holes) into a semiconductor. We have two main targets:

  1. Study of electroluminescence process into optical feedback

We are studying electroluminescence form organic compounds working in different light-matter coupling regimes: weak (WC), strong (SC) and ultrastrong (USC). In the WC the Fermi golden rule is changed by managing the photonic density of states (and the related Purcell effect) through the placement of the active material into an optical feedback (i.e. a dielctricmicrovavity).  We have exploited this effect to improve the efficiency of white OLEDs owing to the coupling of three metal microcavities. ITO-free devices with anefficiecy of 40lm/W in a full coupled microcavity diodes even on flexible substrateshave been developed.

SC and USC regimes are achieved when the dipoles exchange energy with the cavity at a rate larger than the losses from the cavity and the dephasing of the excitons. In this regime the energy of the cavity and the molecules change generating two hibrid states called polaritons. We work on the study of EL process from polaritons with the aim of developing polariton devices and Bose Einstein condensation under electrical injection.

 Development

a)       Study of electroluminescence process in perovskites(Pero-LEDs)

 

We realize LED based perovskite (Pero-LEDs) based on metal-halide perovskite materials, hybrid organic-inorganic compounds, which are recently making inroads in photovoltaics. These materials feature a unique combination of properties: they can be easily be fabricated, both from solution or thermally evaporated, on any substrate and have bright, colour tunable optical emission, like organics, but their electronic conduction properties resemble those of inorganic semiconductors, with large carrier mobility and diffusion lengths. Unfavorably, the important advantages offered by wet processability are accompanied by disconcerting limitations. It is well known, in fact, how the perovskite morphology, strongly depending on the growth conditions, severely impacts on the device performances, causing an intrinsic irreproducibility of the material chemical-physical properties. Therefore huge efforts have been devoted to the optimization of morphology and processing conditions, in particular by controlling the interactions of the material precursors in solution or with the substrate.A further constraint factor in the spin-coated devices is that the number of layers allowed are limited by their solubility in orthogonal solvents. The fabrication of hetero-structured devices may open ways to increase the number of layers allowing to decouple transport from optical characteristics, thus increasing the overall performances of the device, as already shown in small molecules based Organic LEDs (OLEDs). Vacuum-based deposition represents an excellent technique to achieve high-purity layers and potentially allows for a fine control over the stoichiometry and thickness of the perovskite films, thus their reproducibility. Recently we reported for the first time a fully vapor-deposited hetero-structure perovskite light emitting diode exploiting p-i-n technology, as the first step of an innovative approach to electroluminescent perovskite-based devices embedding electrical doping. The approach presented would potentially lead to a better control of the transport and electroluminescent properties of the device, as well as to the possibility of a wide industrial application. Acting on kinetic and thermodynamic conditions during the thermal deposition we study the impact of morphological and structural characteristics on the electro-optical behavior of the perovskite active layer. Several perovskites are explored in infrared and visible windows of electromagnetic spectrum. Analysis of optical characteristics at high current density both in cw and pulsed conditions is done to understand the bimolecular processes responsible for the light emission in perovskites and the aging of the device, which are fundamental to reach the population inversion and lasing. Indeed contrary to organics, in perovskite materials optical recombination is a bimolecular process, not requiring the formation of an exciton. Therefore the radiative efficiency increases with density, as the probability for electrons and holes to find a recombination partner increases, and becomes the dominant recombination channel, with the emission quantum yield approaching unity.

Development of electroluminescent organic devices for industrial applications

 

 Development2

 

Organic light-emitting diodes (OLEDs) are very promising type of technologies having a wide range of applications. In less than two decades, they have become a commercial reality in display technology (AMOLED). The development of large area white OLEDs (WOLEDs) for general lighting with an almost perfect Rendering Colour Index (CRI) near 100 and a  theoretical efficiency of  200 lum/W, is still a challenge.

More recently, Organic Light Emitting Field Effect Transistor (OLEFET) combining in a single device, the current modulation functions and electrical switching properties of a field effect transistor with light generation capabilities of an organic LED, have been investigated for display applications.

Different scientific approaches are followed to fabricate large area white OLED and efficient OLEFET for practical applications:

– The design and fabrication of a p-i-n microcavity structure (p-i-n MC-OLED) offers the possibility to optimize the outcoupling efficiency and improve the output luminance, through the amplification of the light emission next to the resonance wavelength of the single or coupled microcavity, without changing its electrical behaviour. (link to Ultra High Vacuum (UHV) Kurt. J. Lesker Cluster Tool facility)

– Study of supramolecular aggregates in organic semiconductors, particularly molecular crystal structures, and their integration in OLED devices, in order to minimize typical annihilation phenomena and improve device efficiency at high luminance. (link to Ultra High Vacuum (UHV) Kurt. J. Lesker Cluster Tool facility)

– Implementation of trilayer p-i-n ambipolar OLEFET structure. The doping level results crucial to the capability of emitting light, as well as to the electrical characteristics of the device. The hole and electron current profiles can be tailored in order to create simultaneous flows of opposite charges near and across the active layer, featuring light emission across the whole channel area. Device dimension range from 100um down to a few tens of nanometers. (link to Ultra High Vacuum (UHV) Kurt. J. Lesker Cluster Tool facility; nanofabrication facility)

Facilities & Labs

Device Lab @Lecce

People

Vincenzo_maioranoMaiorano

Vincenzo

CNR Tecnologist

Marco_pugliesePugliese

Marco

Associate PostDoc

Fabrizio_marianoFabrizio

Mariano

Associate PostDoc

Armando_GencoArmando

Genco

PHD Student

Sonia_caralloSonia

Carallo

CNR Technician

Marco MazzeoMarco

Mazzeo

Associate Resercher

Publications

  1. Genco , F. Mariano , S. Carallo , V. L. P. Guerra , S. Gambino , D. Simeone , A. Listorti, Silvia Colella , G. Gigli , and M. Mazzeo FullyVapor-DepositedHeterostructured Light-EmittingDiodeBased on Organo-Metal Halide Perovskite, Advanced Electronic Materials, 1500325 (2016)  DOI: 10.1002/aelm.201500325.
  2. Mazzeo, A. Genco, S.Gambino, D. Ballarini, F. Mangione, O. DI Stefano, S. patanè, S. Savasta, D. Sanvitto, G. Gigli, Ultrastrong light-matter coupling in electrically doped microcavity organic light emitting diodes, Applied Physics Letters Vol: 104,Issue:23 (2014)
  3. Accorsi, S. Carallo, M. Mazzeo, A. Genco, S. Gambino, G. Gigli; A colour tunable microcavity by weak-to-strong coupling regime transition through a light-switchable material Chemical communications Vol: 50,Issue:9(2014)

Other selected Publications

  1. Gambino, S.; Mazzeo M. Genco, Di Stefano, O; Savasta, S; Patane, S ; Ballarini, D ; Mangione, F ; Lerario, G; Sanvitto, D ; Gigli, G Exploring Light-MatterInteractionPhenomena under UltrastrongCoupling Regime, ACS PHOTONICS  (2014) Volume: 1   Issue: 10   Pages: 1042-1048
  2. Mazzeo, F. Mariano, A. Genco, S. Carallo, G. Gigli, High efficiency ITO-free flexible white organic light-emitting diodes based on multi-cavity technology, Organic electronics Vol: 14,Issue: 11 (2013)
  3. Maiorano, A.Bramanti, S.Carallo, R.Cingolani and G.Gigli, Organic light emitting field effect transistor based on ambipolar p-i-n layered structure Appl. Phys. Lett., 96, 133305 (2010)
  4. Mazzeo*, F. Della Sala, F. Mariano, G. Melcarne, S. D’Agostino, Y.Duan, R. Cingolani and G. Gigli Shaping white light through electroluminescent fully organic coupled-microcavities, Advanced Materials, 22, pg. 4696 (2010)

Patents

1) Organic light-emitting diode with microcavity including doped organic layers and fabrica-tion process thereof – , B.Dussert-Vidalet, M.Mazzeo, G.Gigli, M.BenKhalifa, F.DellaSala, V.Maiorano, F.MarianoUS 2011079772 (A1)  07/04/2011 ; N° US8969853 (B2) del 03/03/2015

Also published

  1. FR2926677 (A1) 24/07/2009 ; FR2926677 (B1) del 25/04/2014
  2. EP2235763 (A1) del 06/10/2010
  3. WO 2009090248 del 23/07/2009
  4. CA 2712251 23/07/2009
  5. KR 20110009080 (A) del 27/01/2011; KR101585018 (B1) del 13/01/2016
  6. CN 101978527 del 16/02/2011
  7. JP 2011510441 (A) del 31/03/2011 ; JP5594777 (B2) del 24/09/2014
  8. BRPI0906421 14/07/2015

2)Organic light emitting field effect transistor-V.Maiorano, G.Gigli, EP2545599 A1  16/01/2013

Also published

  1. IT RM20100107 13/09/2011
  2. WO 2011110664A1 15/09/2011

Project

MAAT: Molecular NAnotechnology for HeAlth and EnvironmenT ,  PON R&C 2007-2013 –  (2012-2015)

FT_WOLED: Flexible Transparent White Organic Light Emitting DeviceExecutive Programme for scientific and technological cooperation between Italy and China (2013-2015)

PHOEBUS: Plastic tecHnologies for the realization of Organic solar cells and high Efficiency Bright and Uniform Sources,  (2009-2011)

OLEDs for lighting, Project MIUR FAR 297 (2006-2009).

OLLA: Organic light emitting diodes for lighting, EUFP6 IP, (2005-2008)

Latest News

Loretta del Mercato, si aggiudica l'ERC STARTING GRANT 2017

Loretta del Mercato, si aggiudica  l'ERC STARTING GRANT 2017

uno dei bandi più competitivi a livello europeo.

Lecce, 6 settembre 2017 

Lo European Research Council, che promuove la ricerca di eccellenza in Europa, nei giorni scorsi ha reso noti i nomi dei 406 vincitori della selezione ERC STARTING GRANT 2017, il bando tra i più competitivi a livello internazionale.

Su 3085 progetti presentati, 406 i progetti selezionati a cui sono stati destinati i 605 i milioni di euro di investimento. 48 le nazioni di provenienza dei ricercatori, soltanto 17 gli Italiani che condurranno le loro ricerche nel nostro paese, tra cui Loretta del Mercato, ricercatrice dell'Istituto di Nanotecnologia del Consiglio Nazionale delle Ricerche di Lecce.

Un importante riconoscimento alla ricerca nel settore della medicina di precisione condotta presso il CNR NANOTEC, un indiscusso premio al talento della giovane ricercatrice che, a 38 anni e un contratto a tempo determinato, sarà a capo del progetto "Sensing cell-cell interaction heterogeneity in 3D tumor models: towards precision medicine – INTERCELLMED".

Il progetto, il cui obiettivo è affrontare uno dei problemi più spinosi della ricerca sul cancro, ovvero la difficoltà nel trasformare i risultati delle ricerche scientifiche in applicazioni cliniche per i pazienti e che vedrà coinvolto l'Istituto tumori "Giovanni Paolo II" di Bari, si propone di sviluppare nuovi modelli in vitro 3D di tumore del pancreas, alternativi ai modelli animali, ingegnerizzati con un set di sensori nanotecnologici che consentiranno di monitorare le interazioni delle cellule tumorali con il loro micorambiente, verificare l'appropriatezza delle terapie prima della somministrazione ai pazienti oncologici e quindi prevedere la risposta dei singoli pazienti ad una o più terapie antitumorali.

La realizzazione di queste piattaforme 3D multifunzionali consentirà di superare le evidenti differenze intercorrenti tra "modelli animali" ed esseri umani fornendo dati attendibili ed in tempi più rapidi rispetto ai dati ottenuti tramite lunghi e costosi procedimenti di sperimentazione sugli animali. Le tecnologie e i modelli sviluppati saranno estesi anche ad altre forme di tumori solidi nonché impiegati per studi nell'ambito della ingegneria tissutale e della medicina rigenerativa.

Rassegna stampa e Video

Zeiss Microscopy Technology and Complete Correlative Workflow

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Zeiss Microscopy Technology and Complete Correlative Workflow

Lecce, Italy, 2017 Wednesday July 19th 

CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

Program - PDF

Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

[/vc_column_text][/vc_column][/vc_row]

MCS 2017

International Workshop on Micropropulsion and CubeSats

Bari, Italy, 26 - 27 June 2017

Program - MSC2017

This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.