Microfluidics for Chemistry and Cellbiology


The research group is focused on the application of microfluidics to chemistry and cell biology. The team, which consists of a chemist, a physicist, a biotechnologist, a material engineer and a technician, is strongly interdisciplinary. During the years, the fabrication of microreactors as well as the fine-tuning of the operating conditions to produce nanoformulations have been the relevant target of the group activity. Thanks to expertise in the dynamics of fluids in confined environment and the fabrication of integrated lab-on-chip, the physical/chemical properties and functionalities of (bio)molecules and (bio)materials have been deeply investigated and finely addressed. Recently two biologists joined the microfluidics team, thus the group is also moving towards cell biology in the perspective of using microfluidic technologies to create biomimetic niches and study pathophysiological phenomena with high parametric control. All these activities are currently supported by active projects

People Involved



CNR Researcher

Group Coordinator 



CNR PostDoc



CNR Technician



CNR Researcher



Associate PHD Student



CNR Researcher



CNR PostDoc

Facilities & Labs

Characterization Lab @ Lecce

Bio Lab @ Lecce

NanoFab Lab @ Lecce

Soft and Living Matter Laboratory @ Rome

Linee di Ricerca


Lab on chip
Biosensors & Bioelectronics
Cell biology


Organic Random Lasers


  1. M. Bianco, A. Sonato, A. De Girolamo, M. Pascale, F. Romanato, R. Rinaldi, V. Arima An aptamer-based SPR-polarization platform for high sensitive OTA detection Sensors & Actuators: B. Chemical 314-320 (2017) ISSN: 0925-4005; doi: 10.1016/j.snb.2016.10.056
  2. M. S. Chiriacò, M. Bianco, F. Amato, E. Primiceri, F. Ferrara, V. Arima, G. Maruccio Fabrication of interconnected multilevel channels in a monolithic SU-8 structure using a LOR sacrificial layer Microelectronic Engineering 164, 1, 30-35 (2016) ISSN: 01679317DOI: 10.1016/j.mee.2016.07.006
  3. F. Di Maria, M. Zangoli, I. E. Palamá, E. Fabiano, A. Zanelli, M. Monari, A. Perinot, M. Caironi, V. Maiorano, A. Maggiore, M. Pugliese, E. Salatelli, G. Gigli, I. Viola, G. Barbarella Improving the Property–Function Tuning Range of Thiophene Materials via Facile Synthesis of Oligo/Polythiophene-S-Oxides and Mixed Oligo/Polythiophene-S-Oxides/Oligo/Polythiophene-S,S-Dioxides  Adv. Funct. Mater. 26 (38), 6970-6984 (2016) ISSN:1616-3028 DOI: 10.1002/adfm.201602996.
  4. D. Vergara, P. Simeone, F. Julien, M. Trerotola, A. Giudetti, L. Capobianco, A. Tinelli, C. Bellomo,
I. Fournie, A. Gaballo, S. Alberti, M. Salzet, M. Maffia, Translating epithelial mesenchymal transition markers into the clinic: Novel insights from proteomics EuPA Open Proteomics, 10, 31-41, (2016) ISSN: 2212-9685 doi:10.1016/j.euprot.2016.01.003
  5. M. Bianco, V. Guarino, G. Maruccio, G. Galli, E. Martinelli, G. Montani, R. Rinaldi and V. Arima Non-Biofouling Fluorinated Block Copolymer Coatings for Contact Lenses Sci. Adv. Mater. 7, 1387-1394 (2015). ISSN: 1947-2935; doi: 10.1166/sam.2015.2056
  6. A. Zacheo, A. Quarta,  A. Zizzari,   A. G. Monteduro,   G. Maruccio,  V. Arima and   G. Gigli One step preparation of quantum dot-embedded lipid nanovesicles by a microfluidic device RSC Adv., 5, 98576-98582 (2015) ISSN: 2046-2069; doi: 10.1039/c5ra18862h
  7. A .Zacheo, A. Zizzari, E. Perrone, L. Carbone, G. Giancane, L. Valli, R. Rinaldi and V. Arima Fast and safe microwave-assisted glass channel shaped microstructure fabrication Lab Chip 15, 2395–2399 (2015) ISSN: 1473-0197; doi: 1039/c4lc01419g
  8. V. Arima, P. Watts, and G. Pascali Microfluidics in Planar Microchannels: Synthesis of Chemical Compounds On-Chip Chapter 8 from “Lab-on-a-Chip Devices and Micro-Total Analysis Systems: A Practical Guide” Published: November 5, 2014 by Springer. Editor(s): by Jaime Castillo-León and Winnie E. Svendsen
  9. A .Zizzari,   M. Bianco,   R. Miglietta, L. L. del Mercato, M. Carraro, A. Sorarù, M. Bonchio, G. Gigli, R. Rinaldi, I. Viola, V. Arima, Catalytic oxygen production mediated by smart capsules to modulate elastic turbulence under a laminar flow regime Lab Chip, 14, 4391-4397 (2014) ISSN: 1473-0197; doi: 1039/c4lc00791c
  10. L. del Mercato, M. Carraro, A. Zizzari, M. Bianco, R. Miglietta, V. Arima, I. Viola, C. Nobile, A. Sorar, D. Vilona, G. Gigli, M. Bonchio, R. Rinaldi Catalytic Self-Propulsion of Supramolecular Capsules Powered by Polyoxometalate Cargos Chem. Eur. J. 20, 1 – 6 (2014) ISSN: 0947-6539; doi: 10.1002/chem.201403171

Oldest publications (2011-2013):

  1. I. Viola, N. Ghofraniha, A. Zacheo, V. Arima,  C. Conti, G. Gigli Random laser emission from a paper-based device J. Mat. Chem. C 1, 8128-8133 (2013) ISSN: 2050-7526; doi: 10.1039/c3tc31860e
  2. V. Arima,   G, Pascali,  O. Lade,  H. R. Kretschmer,   I. Bernsdorf,   V. Hammond,  P. Watts,   F. De Leonardis,   M. D. Tarn,  N. Pamme,   B. Z. Cvetkovic,   P. S. Dittrich,   N. Vasovic,   R. Duane,   A. Jaksic,   A. Zacheo,   A. Zizzari,   L. Marra,  E. Perrone,  P. A. Salvadori,   R. Rinaldi Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals Lab on a chip 13, 2328-2336 (2013) ISSN: 1473-0197; doi: 10.1039/c3lc00055a
  3. R. Milani, E. Monogioudi, M. Baldrighi, Cavallo, V. Arima, L. Marra, A. Zizzari, R. Rinaldi, M- Linder, G. Resnati, P. Metrangolo Hydrophobin: fluorosurfactant-like properties without fluorine Soft Matter 9, 6505-6514 (2013) ISSN: 1744683X; doi: 10.1039/c3sm51262b
  4. N. Ghofraniha, I. Viola, A. Zacheo, V. Arima, G. Gigli, C. Conti   Transition from nonresonant to resonant random lasers by the geometrical confinement of disorder Opt. Lett. 38, 5043-5046  (2013) ISSN: 0146-9592; doi: 10.1364/OL.38.005043
  5. M. Bianco, A. Aloisi, V. Arima, M. Capello, S. Ferri-Borgogno, F. Novelli, S. Leporatti and R. Rinaldi Quartz Crystal Microbalance with Dissipation (QCM-D) as tool to exploit antigen-antibody interactions in pancreatic ductal adenocarcinoma detection Biosensors and Bioelectronics 42, 646–652 (2013) ISSN: 0956-5663; doi: 10.1016/j.bios.2012.10.012
  6. B. Z. Cvetković, O. Lade, L. Marra, V. Arima, R. Rinaldi and P. S. Dittrich Nitrogen supported solvent evaporation using continuous-flow microfluidicsRSC Adv. 2, 11117-11122 (2012) ISSN: 20462069; doi: 10.1039/c2ra21876c
  7. V. Arima, M. Bianco, A. Zacheo, A. Zizzari, E. Perrone, L. Marra, R. Rinaldi Fluoropolymers coatings on polydimethylsiloxane for retarding swelling in toluene Thin Solid Films 520, 2293–2300 (2012). ISSN: 0040-6090; doi: 10.1016/j.tsf.2011.09.063
  8. I. Viola, A. Zacheo, V. Arima, A. S. Aricò, B. Cortese, M. Manca, A. Zocco, A. Taurino, R. Rinaldi, G. Gigli The influence of polydimethylsiloxane curing ratio on capillary pressure in microfluidic devices Appl. Surf. Sci. 258, 8032-8039 (2012) ISSN: 0169-4332; doi: 10.1016/j.apsusc.2012.04.164
  9. M. Bianco, I. Viola, M. Cezza, F. Pietracaprina, G. Gigli, R. Rinaldi, V. Arima Microfluidic motion for a direct investigation of solvent interactions with PDMS microchannels Microfluid. Nanofluid. 13, 399-409 (2012) ISSN: 1613-4982; doi: 10.1007/s10404-012-0966-y
  10. G. Montani, V. Arima, G. Maruccio, The Tear Film Interaction with Contact Lenses Chapter 19 from “Ocular surface: Anatomy and Physiology, Disorders and Therapeutic Care” Published: October 18, 2012 by CRC Press. Editor(s): Raul Martin Herranz, University of Valladolid, Spain; Rosa M. Corrales Herran, Baylor College of Medicine, Houston, Texas, USA.
  11. A. Zacheo, V. Arima, G. Pascali, P.A. Salvadori, A. Zizzari, E. Perrone, L. De Marco, G. Gigli, R. Rinaldi, Radioactivity resistance evaluation of polymeric materials for application in radiopharmaceutical production at microscale Microfluid. Nanofluid. 11 (1), 35-44 (2011) ISSN: 1613-4982; doi: 10.1007/s10404-011-0770-0
  12. A. Zizzari, V. Arima, A. Zacheo, G. Pascali, P.A. Salvadori, E. Perrone, D. Mangiullo, R. Rinaldi Fabrication of SU-8 microreactors for radiopharmaceutical production Microelectronic Engineering 88   (8), 1664-1667 (2011) ISSN: 0167-9317; doi: 10.1016/j.mee.2010.12.059


Cluster in Bioimaging – Regione Puglia Bando “Aiuti a Sostegno Cluster Tecnologici Regionali” (2015-2017). PI: Valentina Arima

SISTEMA – Sviluppo di nuove metodologie e strumenti Innovativi per la diagnoSi ed il trattamento Terapeutico di tumori Epiteliali uMAni. Regione Puglia Bando “Aiuti a Sostegno Cluster Tecnologici Regionali” (2015-2017) PI: Antonio Gaballo

Latest News


    September 14-22, 2019


    Science coffee. Tre scienziate si raccontano: Luisa Torsi, Loretta L del Mercato, Eva Degl’Innocenti
    Bari – Fiera del Levante, 20 settembre 2019 – 17.30

    Luisa Torsi, chimica, docente all’Università degli Studi di Bari e alla ABO Akademi University in Finlandia, tra le protagoniste della mostra della Fondazione Bracco .
    Loretta L del Mercato, biotecnologa – Ricercatrice CNR Nanotec. Esperta nell’uso delle nanotecnologie applicate in campo biomedico. Attualmente la ricerca si concentra sullo sviluppo di modelli cellulari di tumore del pancreas che consentano di testare l’efficacia di diverse terapie anticancro. Coordina il progetto ERC-StG “INTERCELLMED” finanziato dal Consiglio europeo della ricerca (Erc).
    Eva Degl’Innocenti, Direttrice MARTA di Taranto

  • ICONS – A Symposium on Colloidal Nanocrystals

    October 10-11, 2019


    Cnr Nanotec Lecce


    The symposium focuses on colloidal semiconductor nanocrystals (also known as quantum dots), which are a central topic in materials science and nanotechnology nowadays. The event will bring together renowned scientists in this research field discussing on fundamentals and future directions of this promising class of materials. (more…)


     01 luglio 2019 – ore 14:15


    Cnr Nanotec Lecce


    Realizzato nell’ambito delle attività del progetto “TecnoMed Puglia – Tecnopolo per la medicina di precisione”, il meeting è dedicato allo studio delle malattie neurodegenerative: dai nuovi biomarcatori alle piu recenti modellizzazioni, per una migliore comprensione dei meccanismi di base e quindi per lo sviluppo di terapie sempre più ritagliate sul singolo paziente.