The expansive growth of electronics based on inorganic, organic and hybrid materials has lead to the development of a number of significant applications, ranging from low-cost photovoltaics (OPV), electronic paper, and organic light-emitting diodes (OLEDs) to radio-frequency identification (RFID) tags and sensors. Recently, a considerable interest is developing around wearable optical devices. For instance, flexible OLEDs are now being integrated into flexible or textile based displays. Wearable optical sensors can track multiple vital signs such as heart rate, blood pressure and oxygen levels. Other applications for wearables include UV detection, measuring pollutant levels, explosive detection, both indoors and outdoors. Our main focus is on the realization and characterization of several types of sensors and optoelectronic devices on substrates of different nature and their combination with other components to realize smart systems. We address the new fabrication challenges, such as the diverse nature of material properties due to low temperature processing; the study of device performances that depend on the proper detection and measurements of a multitude of electro-optical signals. These research activities are carried out in collaboration with CNR-IMM in Lecce.