Patents

An optical system for detecting the concentration of combustion products

Inventors: M.De Vittorio, A.Passaseo, M.LoMascolo, R.Cingolani, A. De Risi, D.Laforgia
Abstract: Optical system for detecting the concentration of combustion operating in situ and at high temperature based on measurement of the optical absorption of a gaseous mixture of combustion products through a photodetecting sensor based on gallium nitride (GaN), aluminium nitride (AlN), indium nitride (InN) and corresponding alloys. The operating temperature of the sensor preferably lies between 500 DEG C and 700 DEG C, but the resistance of the active material permits use at even higher temperatures. This system can be used to measure the concentration of chemical species present in combustion products directly at their outlet, where the high operating temperature makes it possible to avoid fouling of the sensor caused by carbonaceous and non-carbonaceous deposits.; The rate of response of the system is less than or equal to 1 millisecond and makes it possible to adjust the parameters of an associated combustion process control system in real time.

Method and microdevice to identify and/or quantifyanalytes in biological samples

Inventors:  P.P. Pompa, S. Sabella, R. Rinaldi, R. Cingolani, F. Calabi

Abstract: A method and device, based on a film of a luminescent substance, such as colloidal semiconductor nanocrystals dispersed in a polymer matrix, for conducting quantitative and real-time analyses of PCR processes or of biomolecular interactions in genomics and/or proteomics. The optical detection system is based on FRET processes between the luminescent substance (which acts as the donor in the FRET process) and a suitable fluorophore (which acts as the acceptor species) with which the DNA or other biomolecule is marked. The device is essentially composed of a reaction microchamber with a wall formed by a thin film made of polymer material, in which the nanocrystals are uniformly dispersed, or made of a photoluminescent or electroluminescent polymer.; Molecular probes are chemically immobilized on the surface of the polymer film for the specific recognition of the analyte which is to be determined in real time. The film of nanocrystals is excited by radiation at low wavelength (for example, UV/blue), and the radiation in the spectral emission window characteristic of the fluorescent marker of the biomolecule is detected. The specific photophysical characteristics of FRET processes make it possible to monitor in a selective way, in real time and in quantitative mode, the biomolecular interactions, which take place in the close proximity of the surface of the film (typically at distances of < 10 nanometres), thus almost completely reducing possible interference caused by background signals and by the free biomolecules in solution (which have not interacted with the corresponding recognition sites).; The characteristics of the device also enable simultaneous analyses to be conducted in parallel on different biomolecules (multiplexing).

Electrical transduction method and device for the detection of biorecognition events in biomolecular interaction processes for genome/proteonome analysis

Inventors: G.Maruccio, E.Primiceri, P.Marzo, V.Arima, R. Krahne, T.Pelelgrino, A.Della Torre, F.Calabi, R.Cingolani, R.Rinaldi

Abstract: A method is described for detecting biorecognition events in biomolecular interaction processes, including the provision, on at least one biorecognition site, of molecular probes (P) adapted to interact with target molecular species (T) which are coupled to conductive nanoparticles (NP), in which the probes (P) are associated with a nanojunction transducer device (12) comprising a pair of conductive electrodes (22, 24) separated by a nanometric gap of the same order of magnitude as the dimensions of said conductive nanoparticles (NP), adapted to detect a condition of coupling between at least one molecular probe (P) and a specimen of a target species (T) which interact with each other.; A biorecognition event includes the coupling of a probe (P) to at least one specimen of the target species (T) and results in the positioning of the conductive nanoparticle (NP) coupled to the target species (T) (by being directly conjugated with the latter or with a signal molecule which can interact with it) between the electrodes (22, 24) of the nanojunction device (12), with the consequent creation of a conductive path between the electrodes. The occurrence of biorecognition events is evaluated according to the intensity of the current which is made to flow between the electrodes (22, 24) of the nanojunction device (12) by the application of a potential difference.

Apparatus for cytofluorimetric analyses and methods for optimizing the conditioningchain

Inventors: G.Gigli, M.Esposito.

Abstract: There is disclosed an apparatus for cytofluorimetric analyses including an optical system, based on at least one multi-channel photomultiplier allowing to condition the signals exclusively in the digital domain by means of a conditioning chain formed by routine software, the specific optimal operation parameters of which are obtained by means of methods which are also an object of the present invention, thus obtaining an efficiency which is so high that it allows more reliable and detailed analyses than in the past.

Apparatusfor cytofluorimetricanalyses

Inventors: G.Gigli, M.Esposito

Abstract: There is disclosed an apparatus for cytofluorimetric analyses including an optical system, in which the main functionalities rely on a multi-channel photomultiplier (PMT), and in which the integral replacement of the electronic circuitry for the conditioning and processing of the signals is made possible by means of routine software so as to strongly decrease the background noise and allow more reliable and detailed analyses.

Integratedmagnetictriaxialsensor

Inventors: M.T Todaro, L.Sileo, V.Tasco, M.De Vittorio, R.Cingolani, A.Passaseo, C.Giordano
Abstract: The present invention concerns an integrated triaxial magnetic sensor device 100 apt to detect a magnetic field comprising: a substrate 120 having a surface defining a reference plane (x,y); a first sensor unit 101 arranged on a first main surface 121 of the substrate in a first plane substantially parallel to the reference plane; a second sensor unit 102 arranged on a second plane, and a third sensor unit 103 arranged on a third plane, the second and third planes being not parallel to the reference plane.; The device further comprises: a first cantilever structure 115 raised with respect to the reference plane by a first elevation angle and having a second main surface 125 arranged along the second plane, the first cantilever structure including the second sensor unit 102, and a second cantilever structure 116 raised with respect to the reference plane by a second elevation angle and having a third main surface 126 arranged along the third plane, the second cantilever structure including the third sensor unit 103, in which the first and the second cantilever structure are structurally connected to the substrate 120 through a respective first and second hinge structure 113, 114 curved with respect to the reference plane and bearing the respective cantilever structure while maintaining it raised with respect to the reference plane.

Organic light-emittingdiode with microcavityincludingdopedorganiclayers and fabricationprocessthereof

Inventors: M.Ben Khalifa, F.Della Sala, B.Dussert-Vidalet, G.Gigli, V.Maiorano,F.Mariano, M.Mazzeo

Abstract: An organic light emitting diode (OLED) emitting light downward through a transparent substrate (240) is described. The OLED embeds a microcavity (220) formed between a cathode (210) and an anode (230) and includes a plurality of organic layers comprising a light emitting layer (225). It is characterized in that the plurality of organic layers includes at least a first layer (229) made of an organic doped material aimed at enhancing the transport of holes; the plurality of organic layers also includes at least a second layer (221) made of an organic doped material aimed at enhancing the transport of electrons. The OLED is further characterized in that the anode i (230) is obtained by deposition of a semi transparent layer of silver (Ag) over the transparent substrate to be directly in contact with the first doped organic layer (229).; Then, thicknesses of the first and second doped organic layers can be freely adapted to best adjust the optical characteristics of the microcavity for the wavelength of monochromatic light to be produced by the OLED

OpticalLogic Gate

Inventors: Bovino Fabio Antonio, Giardina Maurizio, Larciprete Maria Cristina, Centini Marco, Belardini Alessandro, Sibilia Concita, Bertolotti Mario, Passaseo Adriana, TascoVittorianna, Cingolani Roberto

Abstract: Optical logic gate having a second-harmonic generator element that receives a first and a second optical input signal respectively having a first and a second angular frequency and respectively having a first and a second polarization, and which provides a second-harmonic optical signal having a third angular frequency and a third polarization. The third angular frequency is equal to the sum of the first and the second angular frequency. The third polarization is a function of the first and the second polarization. The second-harmonic generator element includes a second-harmonic generator layer in a material having a non-null second-order optical tensor.

Double layer coating, its preparation and its use for rendering ultra water-repellent and antireflective the surfaces to which it is applied

Double layer coating, its preparation and its use for rendering ultra water-repellent and antireflective the surfaces to which it is applied

Inventors: M.Manca, L.De Marco, G.Gigli

Abstract: The present invention relates to a double layer coating formed of a first layer (lower layer) of photo/thermosetting resin and a second later (upper layer) comprising hydrophobic microparticles partially incorporated in a matrix of photo/thermosetting resin. The application of said coating is an effective method for generating ultra water-repellent and antireflective surfaces.

Organic light emitting field effect transistor

Inventors: V.Maiorano, G.Gigli

Abstract: The present invention relates to an organic light emitting field effect transistor, OLEFET, (10) comprising a gate (G), a source (S) and a drain (D) electrode; a layered organic stack structure (1) including an organic layer (4) with predominant hole transporting character, an organic layer (2) with predominant electron transporting character and an organic active layer (3) having light emitting properties,the organic active layer (3) being interposed between the predominant hole and electron doped transport layers (4,2). The organic layer (4) with predominant hole transporting character and/or the organic layer (2) with predominant electron transporting character is doped in order to enhance the transport of holes/electrons. In addition, the layered organic stack structure (1) is positioned between said gate (G) and said source-drain electrodes

Electro-Active Microelectromechanical Device And Corresponding Detection Process

Inventors: A. Qualtieri, F. Rizzi, M. De Vittorio, A. Passaseo, M. T. Todaro, G. Epifani

Abstract: An electroactivemicroelectromechanical device of the Artificial Hair Cell type includes a moving cilium structure having a substrate and a cantilever, partly or entirely in piezoelectric material, subject to bending or deformation following the action of a force and/or an applied voltage. The cantilever includes a multilayer inducing a stress-driven geometry in which a portion of the cantilever lies outside of a plane defined by the substrate. According to the invention, the cantilever is associated to a piezoresistive element, in particular of piezoresistive material configured to measure the bending or deformation of the cantilever.

Photovoltacromic device with intedigitated electrodes

Inventors: M.Manca, A.Cannavale, G.Gigli, R.Cingolani

Abstarct: A photovoltachromic device (50) having a photoelectrode (86) and a counterelectrode (66), the counterelectrode including an electrochromic region (70) and a catalytic region (72) that are physically separate. The electrochromic region and the catalytic region are interdigitated.

Impedenziometric biochip useful for detecting infections of e.g. Candida Albicans andStreptococcus Agalactiae by drawing and analysis of vaginal fluid whose presence isdetected via impedance variation measurable within special electrodes

Inventors: D. Carati, M. S. Chiriaco, F. De Feo, G. Maruccio, M. Megha, A. Montanaro, E. Primiceri,A.Tinelli.

Abstarct: The object of the present invention is to provide an impedimetric biochip for the simultaneous diagnosis of gynecological pathologies related to C. albicans, S. agalactiae or C.trachomatis by using the vaginal fluid of the patient. This invention enables a significant reduction of examination times if compared with the present-day techniques. Another important feature of the present invention is its ability to provide a highly sensitive detection, accurate and specific for the described diseases.

Cancer Therapy with silver nanoparticles

Inventors: I.Palamà,  M.Pollini, F. Paladini, G.Accorsi,  A. Sannino, G.Gigli,

Abstract: The present invention provides methods for inhibiting or preventing cancer cell growth using silver nanoparticles.

High-efficiency nanodiamond-based ultraviolet photocathodes

Inventors: A. Valentini, D. Melisi, G. De Pascali, G. Cicala, L. Velardi, A. Massaro,

Abstract: Method for the production of high efficiency photocathodes for ultraviolet based on nanodiamonds, comprising providing a support capable of conducting electrons, and producing a photosensitive layer of nanodiamonds on the support.

Production of the photosensitive layer includesproviding nanodiamond particles in the form of powder,hydrogenating the nanoparticles in a H2 plasma,preparing a dispersion of the hydrogenated particles in a solvent, and spraying the dispersion onto the support and waiting for the solvent to evaporate from the support, the spray and waiting cycle being repeated several times in order to obtain a continuous photosensitive layer.

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