Statistical Physics

Mission

The Statistical Physics group is a theoretical research team interested in the statistical mechanics of disordered systems applying related techniques, both analytic and computational, to a large variety of complex problems. The group activity is mainly related to

  • deepen and solve old and new open issues in the theory of structural glasses and theories for systems with intrinsic frustration such as spin-glasses,
  • investigate constraint satisfaction and optimisation problems and the structure of solutions in the hard computational cases.
  • test and develop methods for statistical inference in the general framework of solving inverse problems,
  • adapt and apply statistical mechanics to photonics in presence of nonperturbative disorder, ranging from light propagation in random media to random lasers,
  • investigate biological organisms by means of theoretical methods and mathematical modeling, analyse the interaction of biological structures at the molecular level and the connections among different subsystems in large-scale networks through computer simulations, with a focus on proteins and metabolism,
  • study turbulence, intermittency and dissipative processes in non-collisional plasmas through theoretical investigation, numerical simulations and data analysis,
  • develop and test parallel computation on single and multi GPU for continuous variables Monte Carlo dynamics, Population dynamics for Belief propagation and Cavity method in random graphs, and Pseudolikelihood maximisation.

 

People Involved

Andrea

De Martino

CNR Researcher

Group Supervisor

Luca

Sorriso-Valvo

CNR Researcher

Alessia

Marruzzo

Post Doc CNR Associate

Federico

Ricci-Tersenghi

CNR Associate, Università La Sapienza

Luca

Leuzzi

CNR Researcher

Group Supervisor

Payal

Tyagi

CNR PostDoc

Giorgio

Parisi

CNR Associate, Università La Sapienza

Bruno

Rizzuti

CNR Reseacher

Fabrizio

Antenucci

Post Doc CNR Associate

Enzo

Marinari

CNR Associate, Università La Sapienza

Facilities & Labs

GPU clusters @ Department of Physics of Sapienza University

Research Lines

Publications

  1. P Tyagi, A Marruzzo, A Pagnani, F Antenucci, L Leuzzi, Regularization and decimation pseudolikelihood approaches to statistical inference in XY-spin models, Physical Review B 94, 024203 (2016), Doi: 10.1103/PhysRevB.94.024203.
  2. A Marruzzo, L Leuzzi, Multi-body quenched disordered XY and p-clock models on random graphs. Physical Review B 93, 094206 (2016) Doi: 10.1103/PhysRevB.93.094206.
  3. M Mori, T Hwa, OC Martin, A De Martino and E Marinari. Constrained Allocation Flux Balance Analysis. PLoS Comp Biol 12:e1004913 (2016) Doi: 10.1371/journal.pcbi.1004913
  4. A Martirosyan, M Figliuzzi, E Marinari and A De Martino. Probing the limits to microRNA-mediated control of gene expression. PLoS Comp Biol 12: e1004715 (2016) Doi: 10.1371/journal.pcbi.1004715
  5. D De Martino et al, Growth against entropy in bacterial metabolism: the phenotypic trade-off behind empirical growth rate distributions in E. coli, Phys Biol 13:036005 (2016). DOI:1088/1478-3975/13/3/036005
  6. S Grigolon et al, Noise Processing by MicroRNA-Mediated Circuits: the Incoherent Feed-Forward Loop, Revisited, Heliyon 2:e00095 (2016). DOI:  1016/j.heliyon.2016.e00095
  7. F Antenucci, A Crisanti, M Ibáñez-Berganza, A Marruzzo, L Leuzzi, Statistical mechanics models for multimode lasers and random lasers.  Philosophical Magazine 96, 704-731 (2016) Doi: 10.1080/14786435.2016.1145359.
  8. F Antenucci, Statistical Physics of Wave Interactions, Springer (2016).
  9. R Marino, G Parisi, F Ricci-Tersenghi, The backtracking survey propagation algorithm for solving random K-SAT problems, Nat. Common. 7, 12996 (2016),  DOI: 10.1038/ncomms12996.
  10. A Decelle, F Ricci-Tersenghi, Data quality for the inverse Ising problem, J. Phys. A 49,  384001 (2016),  DOI: 10.1088/1751-8113/49/38/384001
  11. A Decelle, F Ricci-Tersenghi,  Solving the inverse Ising problem by mean-field methods in a clustered phase space with many states,  Phys. Rev. E 94, 012112 (2016) DOI: 10.1103/PhysRevE.94.012112
  12. P Contucci, E Panizzi, F Ricci-Tersenghi, A Sirbu, Egalitarianism in the rank aggregation problem: a new dimension for democracy, Quality and Quantity, 50, 1185 (2016), DOI: 10.1007/s11135-015-0197-x
  13. A Javanmard, A Montanari, F Ricci-Tersenghi, Phase transitions in semidefinite relaxations, 113, E2218 (2016), DOI: 10.1073/pnas.1523097113
  14. I Maccari, A Maiorano, E Marinari, JJ Ruiz-Lorenzo, JJ, A numerical study of planar arrays of correlated spin islands, Eur. Pays. J B  89, 127 (2016),  DOI: 10.1140/epjb/e2016-70171-x
  15. LA Fernandez et al., Universal critical behavior of the two-dimensional Ising spin glass, Phys. Rev. B 94, 024402 (2016),  DOI: 10.1103/PhysRevB.94.024402
  16. F Valentini, D Perrone, S Stabile, O Pezzi, S Servidio, R De Marco, F Marcucci, R Bruno, B Lavraud, De Keyser, G Consolini, D Brienza, SorrisoValvo L, A Retinò, A Vaivads, M Salatti and P Veltri (2016). Differential kinetic dynamics and heating of ions in the turbulent solar wind. NEW JOURNAL OF PHYSICS, 18, 125001 (2016), doi:10.1088/1367-2630/18/12/125001
  17. Pucci F, Malara F, Perri S, Zimbardo G, SorrisoValvo L, Valentini F, Energetic particle transport in the presence of magnetic turbulence: influence of spectral extension and intermittency. MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, 459, 3395 (2016), doi: 10.1093/mnras/stw877
  18. Malara F, Di Mare F, Nigro G, SorrisoValvo L , Fast algorithm for a three-dimensional synthetic model of intermittent turbulence. PHYSICAL REVIEW. E, 94, 053109 (2016), doi: 10.1103/PhysRevE.94.053109
  19. Leonardis E, SorrisoValvo L, Valentini F, Servidio S, Carbone F, Veltri P (2016). Multifractal scaling and intermittency in hybrid Vlasov-Maxwell simulations of plasma turbulence. PHYSICS OF PLASMAS, 23, 022307 (2016), doi: 10.1063/1.4942417
  20. S Evoli, DL Mobley, R Guzzi, B Rizzuti, Multiple binding modes of ibuprofen in human serum albumin identified by absolute binding free energy calculations, Phys. Chem. Chem. Phys. 18 32358-32368 (2016), DOI: 10.1039/C6CP05680F
  21. JL Neira, S Martínez-Rodríguez, JG Hernández-Cifre, A Cámara-Artigas, P Clemente, S Peralta, MÁ Fernández-Moreno, R Garesse, J García de la Torre, B Rizzuti, Human COA3 is an oligomeric highly flexible protein in solution, Biochemistry 55 6209-6220 (2016), DOI: 10.1021/acs.biochem.6b00644
  22. JL Neira, B Rizzuti, JL Iovanna, Determinants of the pKa values of ionizable residues in an intrinsically disordered protein, Arch. Biochem. Biophys. 598 18-27 (2016), DOI: 10.1016/j.abb.2016.03.034
  23. F Antenucci, MI Berganza, L Leuzzi, Statistical physics of nonlinear wave interaction,  Physical Review B 92, 014204 (2015) Doi: 10.1103/PhysRevB.92.014204 .
  24. F Antenucci, C Conti, A Crisanti, L Leuzzi, General phase diagram of multimodal ordered and disordered lasers in closed and open cavities.  Physical Review Letters 114, 043901 (2015) Doi: 10.1103/PhysRevLett.114.043901 .
  25. F Antenucci, A Crisanti, L Leuzzi, The glassy random laser: replica symmetry breaking in the intensity fluctuations of emission spectra,  Scientific reports 5, 16792 (2015) Doi:10.1038/srep16792.
  26. N Ghofraniha, I Viola, F Di Maria, G Barbarella, G Gigli, L Leuzzi, C Conti, Experimental evidence of replica symmetry breaking in random lasers,  Nature communications 6, 5 (2015) Doi:10.1038/ncomms7058.
  27. F Capuani et al, Quantitative constraint based computational model of tumor-to-stroma coupling via lactate shuttle, Sci Rep 5:11880 (2015). DOI: 10.1038/srep11880
  28. A Marruzzo, L Leuzzi, Nonlinear XY and p-clock models on sparse random graphs: Mode-locking transition of localized waves, Physical Review B 91, 054201 (2015) Doi: 10.1103/PhysRevB.91.054201.
  29. C Rainone, U Ferrari, M Paoluzzi, L Leuzzi, Dynamical arrest with zero complexity: The unusual behavior of the spherical Blume-Emery-Griffiths disordered model, Physical Review E 92, 062150 (2015)DOI: 10.1103/PhysRevE.92.062150 .
  30. L Leuzzi, G Parisi, F Ricci-Tersenghi, JJ Ruiz-Lorenzo,Infinite volume extrapolation in the one-dimensional bond diluted Levy spin-glass model near its lower critical dimension, Physical Review B 91, 064202 (2015) DOI: 10.1103/PhysRevB.91.064202.
  31. A Crisanti, L Leuzzi, A simple spin model for three step relaxation and secondary processes in glass formers, Journal of Non-Crystalline Solids 407, 110-117 (2015) DOI: 10.1016/j.jnoncrysol.2014.07.048.
  32. P Tyagi, A Pagnani, F Antenucci, M Ibanez Berganza, L Leuzzi, Inference for interacting linear waves in ordered and random media,  Journal of Statistical Mechanics: Theory and Experiment 2015 (5), Doi: 10.1088/1742-5468/2015/05/P05031
  33. F Antenucci, A Crisanti, L Leuzzi, Complex spherical 2+ 4 spin glass: A model for nonlinear optics in random media,  Physical Review A 91, 053816 (2015) Doi: 10.1103/PhysRevA.91.053816.
  34. F Antenucci, M Ibanez Berganza, L Leuzzi, Statistical physical theory of mode-locking laser generation with a frequency comb.  Physical Review A 91, 043811 (2015) Doi: 10.1103/PhysRevA.91.043811.
  35. S Franz, G Parisi, F Ricci-Tersenghi, P Urbani, Quasi equilibrium construction for the long time limit of glassy dynamics, JSTAT P10010 (2015), 10.1088/1742-5468/2015/10/P10010
  36. C Schulke, F Ricci-Tersenghi, Multiple phases in modularity-based community detection, Phys. Rev. E, 92, 042804 (2015),  DOI: 10.1103/PhysRevE.92.042804
  37. G Parisi, F Ricci-Tersenghi, D Yllanes, Explicit generation of the branching tree of states in spin glasses,  JSTAT P05002 (2915), DOI: 10.1088/1742-5468/2015/05/P05002
  38. G Parisi, F Ricci-Tersenghi, T Rizzo, Diluted mean-field spin-glass models at criticality, JSTAT  E03001 (2015), DOI: 10.1088/1742-5468/2015/03/E03001
  39. C Capone, C Filosa, G Gigante, F Ricci-Tersenghi, P Del Giudice, Inferring Synaptic Structure in Presence of Neural Interaction Time Scales, Plos One 10, e0118412 (2016),  DOI: 10.1371/journal.pone.0118412
  40. C Cammarota, E Marinari, Spontaneous energy-barrier formation in entropy-driven glassy dynamics, Phys. Rev. E 92, 0130301 (2015),  DOI: 10.1103/PhysRevE.92.010301 
  41. MS Mariani, G Parisi, C Rainone, Calorimetric glass transition in a mean-field theory approach,
  42. PNAS 112, 2361 (2015),  DOI: 10.1073/pnas.1500125112
  43. SorrisoValvo L, Marino R, Lijoi L, Perri S, Carbone V. SELF-CONSISTENT CASTAING DISTRIBUTION OF SOLAR WIND TURBULENT FLUCTUATIONS. THE ASTROPHYSICAL JOURNAL, 807 (2015), doi:10.1088/0004-637X/807/1/86
  44. SorrisoValvo L, G. De Vita, M. Kazachenko, S. Krucker, L. Primavera, S. Servidio, A. Vecchio, B. Welsch, G. Fisher, F. Lepreti, V. Carbone. Sign singularity and flares in solar active region NOAA 11158. THE ASTROPHYSICAL JOURNAL, 801, 36 (2015), doi:10.1088/0004-637X/801/1/36
  45. Chasapis A., Retinò A., Sahraoui F., Vaivads A., Khotyaintsev Y., Sundkvist D., Greco A., SorrisoValvo L, Canu P.. Thin current sheets and associated electron heating in turbulent space plasma. THE ASTROPHYSICAL JOURNAL LETTERS, 804, L1 (2005), doi: 10.1088/2041-8205/804/1/L1
  46. Rossi, F. Califano, A. Retinò, SorrisoValvo L, P. Henri, S. Servidio, F. Valentini, A. Chasapis, L. Rezeau. Two-fluid numerical simulations of turbulence inside Kelvin-Helmholtz vortices: Intermittency and reconnecting current sheets. PHYSICS OF PLASMAS, vol. 22, 122303 (2015), doi: 10.1063/1.4936795
  47. Carbone F, Ciuchi F, Mazzulla A, SorrisoValvo L , Anomalous Scaling, Intermittency and Turbulence in Nematic Liquid Crystals. MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 614, 67 (2015), doi: 10.1080/15421406.2015.1049911
  48. Yordanova E., Perri S., SorrisoValvo L, Carbone V. Multipoint observation of anisotropy and intermittency in solar-wind turbulence. EUROPHYSICS LETTERS, 110, 19001 (2015), doi: 10.1209/0295-5075/110/19001
  49. B Rizzuti, R Bartucci, L Sportelli, R Guzzi, Fatty acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation, Arch Biochem Biophys. 579 18-25 (2015), DOI: 10.1016/j.abb.2015.05.018

Other Selected Publications

  1.  M Figliuzzi et al, RNA based regulation: dynamics and response to perturbations of competing RNAs. Biophys J 107:1011 (2014) Doi: 10.1016/j.bpj.2014.06.035.
  2. D De Martino, F Capuani and A De Martino. Inferring metabolic phenotypes from the exometabolome through a thermodynamic variational principle. New J Phys 16: 115018 (2014) Doi: 10.1088/1367-2630/16/11/115018
  3. A De Martino, D De Martino, R Mulet and A Pagnani. Identifying all moiety conservation laws in genome-scale metabolic networks, PLoS ONE 9:e100750  (2014)  Doi: 10.1371/journal.pone.0100750
  4. A Seganti, F Ricci Tersenghi and A De Martino. Searching for feasible stationary states in reaction net- works by solving a Boolean constraint satisfaction problem. Phys Rev E 89:022139 (2014) Doi: 10.1103/PhysRevE.89.022139
  5. FL Metz, G Parisi,  L Leuzzi, Finite-size corrections to the spectrum of regular random graphs: An analytical solution. Physical Review E 90, 052109 (2014)DOI: 10.1103/PhysRevE.90.052109 .
  6. F Antenucci, A Crisanti, L Leuzzi, Small-cluster renormalization group in Ising and Blume-Emery-Griffiths models with ferromagnetic, antiferromagnetic, and quenched disordered magnetic interactions,  Physical Review E 90, 012112 (2014) DOI: 10.1103/PhysRevE.90.012112.
  7. F Antenucci, A Crisanti, L Leuzzi, Critical Study of Hierarchical Lattice Renormalization Group in Magnetic Ordered and Quenched Disordered Systems: Ising and Blume–Emery–Griffiths Models,  Journal of Statistical Physics 155, 909-931 (2014) DOI: 10.1 007/s10955-014-0977-z .
  8. FL Metz, L Leuzzi, G Parisi, Renormalization flow of the hierarchical Anderson model at weak disorder, Physical Review B 89, 064201 (2014) DOI: 10.1103/PhysRevB.89.064201
  9. A Crisanti, L Leuzzi, Large Deviations in Physics, Large Deviations in Disordered Spin Systems,  Springer, 135-160 (2014) .
  10. C Lucibello, F Morone, G Parisi, F Ricci-Tersenghi, T Rizzo,  Anomalous finite size corrections in random field models, JSTAT P10025 (2014),  DOI: 10.1088/1742-5468/2014/10/P10025
  11. E Brezin, G Parisi, F Ricci-Tersenghi,The Crossover Region Between Long-Range and Short-Range Interactions for the Critical Exponents,  J. Stat. Phys. 157, 855 (2014), DOI: 10.1007/s10955-014-1081-0
  12. A Lage-Castellanos, R Mulet, F Ricci-Tersenghi, Message passing and Monte Carlo algorithms: Connecting fixed points with metastable states, EPL 107, 57011 (2014) DOI: 10.1209/0295-5075/107/57011
  13. C Lucibello, F Morone, G Parisi, F Ricci-Tersenghi, T Rizzo, Finite-size corrections to disordered Ising models on random regular graphs, Phys. Rev. E 90,  012146 (2014),  DOI: 10.1103/PhysRevE.90.012146
  14. M Baity-Jesi et al., JSTAT P05014 (20014), DOI: 10.1088/1742-5468/2014/05/P05014
  15. MC Angelini, G Parisi, F Ricci-Tersenghi, Phys. Rev. E 89, 062120 (2014), DOI: 10.1103/PhysRevE.89.062120
  16. F Morone, G Parisi, F Ricci-Tersenghi, Large deviations of correlation functions in random magnets, Phys. Rev. B 89, 214202 (2014), DOI: 10.1103/PhysRevB.89.214202
  17. G Parisi, F Ricci-Tersenghi, T  Rizzo, Diluted mean-field spin-glass models at criticality, JSTAT P04013 (2014),  DOI: 10.1088/1742-5468/2014/04/P04013
  18. M Baity.Jesi et al., Dynamical transition in the D=3 Edwards-Anderson spin glass in an external magnetic field, Phys. Rev. E 89, 032140 (2014), DOI: 10.1103/PhysRevE.89.032140
  19. L Nicolao, G Parisi, F Ricci-Tersenghi, Spatial correlation functions and dynamical exponents in very large samples of four-dimensional spin glasses, Phys. Rev. E 89, 032127 (2014) DOI: 10.1103/PhysRevE.89.032127
  20. A Decelle, F Ricci-Tersenghi, Pseudolikelihood Decimation Algorithm Improving the Inference of the Interaction Network in a General Class of Ising Models, Phys. Rev. Lett. 112, 070603 (2014),  DOI: 10.1103/PhysRevLett.112.070603
  21. A Billoire et al., Cumulative overlap distribution function in realistic spin glasses, Phys. Rev. B 90, 094201 (2014), DOI: 10.1103/PhysRevB.90.094201
  22. P Charbonneau et al., Exact theory of dense amorphous hard spheres in high dimension. III. The full replica symmetry breaking solution, JSTAT P10009 (2014)  DOI: 10.1088/1742-5468/2014/10/P10009
  23. De Vita G, SorrisoValvo L, Valentini F, Servidio S, Primavera L, Carbone V and Veltri P Analysis of cancellation exponents in two-dimensional Vlasov turbulence. PHYSICS OF PLASMAS,  21, 072315 (2014), doi: 10.1063/1.4891339
  24. Carbone F, SorrisoValvo L. Experimental analysis of intermittency in electrohydrodynamic instability. THE EUROPEAN PHYSICAL JOURNAL. E, SOFT MATTER, 37, 61 (2014), doi: 10.1140/epje/i2014-14061-x
  25. Chen C H K, SorrisoValvo L, Safrankova J, Nemecek Z. INTERMITTENCY OF SOLAR WIND DENSITY FLUCTUATIONS FROM ION TO ELECTRON SCALES. THE ASTROPHYSICAL JOURNAL, 789, L8  (2014), doi: 10.1088/2041-8205/789/1/L8
  26. Bruno R, Telloni D, Primavera L, Pietropaolo E, D’Amicis R, SorrisoValvo L, Carbone V, Malara F, Veltri P, RADIAL EVOLUTION OF THE INTERMITTENCY OF DENSITY FLUCTUATIONS IN THE FAST SOLAR WIND. THE ASTROPHYSICAL JOURNAL,  786, 53 (2014), doi: 10.1088/0004-637X/786/1/53
  27. S Evoli, R Guzzi, B Rizzuti, Molecular simulations of ß-lactoglobulin complexed with fatty acids reveal the structural basis of ligand affinity to internal and possible external binding sites, Proteins 82 2609-2619 (2014), DOI: 10.1002/prot.24625
  28. M Pantusa, R Bartucci, B Rizzuti, Stability of trans-resveratrol associated with transport proteins, J Agric Food Chem 62 4384-4391 (2014), DOI: 10.1021/jf405584a

Latest News

  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

  • Workshop annuale d’Istituto – II ed.

    Workshop annuale d’Istituto – II ed.

    Cetraro (CS), 3 -5 maggio 2017

    Il programma completo dell’evento – download

    La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

ToMA Lab – Tomography for Medical Application

Mission

• Researchmainly focused on the progress and translation of modern x-ray physics concepts to biomedical sciences, exploiting the long-standing experience in X-ray optics and X-ray imaging.
• Education for Diploma, and PhDstudentsinterested in biomedicalimaging and x-rayoptics

Link http://www.sapienza-cnrnanotec.it/tomalab/index.html

People Involved

Alessia

Cedola

CNR Researcher

Group Coordinator 

Fabrizio

Bardelli

Associate Researcher, Marie-Curie

Inna

Bukreeva

CNR Researcher

Francesco

Brun

Associate PostDoc

Michela

Fratini

CNR Researcher

Lorenzo

Massimi

Associate PostDoc

Facilities & Labs

Advanced X-ray @ Roma

Linee di Ricerca

Publications

  1. Recent advances in superhydrophobic surfaces and their relevance to biology and medicine.Ciasca G., Papi M., Businaro L., Campi G., Ortolani M., Palmieri V., Cedola A., De Ninno A., Gerardino A., Maulucci G., De Spirito M. . Bioinspiration&biomimetics 11 (1), 011001, 2016.
  2. Virtual unrolling and deciphering of Herculaneumpapyri by X-rayphase-contrasttomography, I. Bukreeva et al. Scientific Reports6, Article number: 27227 (2016).http://www.nature.com/articles/srep27227.
  3. Characterization of mouse spinalcordvascular network by means of synchrotronradiation X-rayphasecontrasttomography, L. Massimi et al, Physica Medica 2016, http://dx.doi.org/10.1016/j.ejmp.2016.09.015.
  4. X-ray micro-beam techniques and phase contrast tomography applied to biomaterials. Fratini M., Campi G., Bukreeva I., Pelliccia D., Burghammer M., Tromba G., Cancedda R., Mastrogiacomo M., Cedola A. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 364, 93-97, 2015.
  5. Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord. Michela Fratini, Inna Bukreeva, Gaetano Campi, Francesco Brun, Giuliana Tromba, Peter Modregger, Domenico Bucci, Giuseppe Battaglia, Raffaele Spadon, Maddalena Mastrogiacomo, HerwigRequardt, Federico Giove, Alberto Bravin, Alessia Cedola. Scientific Reports 5, 8514, 2015.http://www.nature.com/articles/srep08514.
  6. Imaging collagen packing dynamics during mineralization of engineered bone tissue. Campi, G., Fratini, M., Bukreeva, I., Ciasca, G., Burghammer, M., Brun, F., … & Cedola, A. Acta biomaterialia, 23, 309-316, 2015.
  7. High-resolution X-ray techniques as new tool to investigate the 3D vascularization of engineered-bone tissue. Bukreeva, I., Fratini, M., Campi, G., Pelliccia, D., Spanò, R., Tromba, G., … & Cedola, A. Frontiers in bioengineering and biotechnology, 3, 133, 2015.
  8. G.Campi,M.Fratini,I.Bukreeva,G.Ciasca,M.Burghammer,F.Brun,G.Tromba, M.Mastrogiacomo, andA.Cedola,Imagingcollagenpackingdynamicsduringmineralizationof engineeredbonetissue ACTA BIOMATERIALIA  Volume: 23   Pages: 309-316   Published: SEP 1 2015

Projects

• Europeanproject VOXEL “VolumetricMedical X-RayImagingatextremelylow dose” (HORIZON 2020-Fet Open; Project reference: 665207).
• BiominAB-3D – Revealing the composition and formationmechanism of carcinogenicasbestosbodies in human lungs; MSCA-IF-2015-EF – Marie Skłodowska-Curie IndividualFellowships (IF-EF), Marie Skłodowska-Curie IndividualFellowships (2016-2018)

Latest News

  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

  • Workshop annuale d’Istituto – II ed.

    Workshop annuale d’Istituto – II ed.

    Cetraro (CS), 3 -5 maggio 2017

    Il programma completo dell’evento – download

    La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

Particle – Based Plasma Virtual Lab

Mission

Development of models, at different time scales and length, based on the particle representation (Particle-in-Cell, Monte Carlo and Molecular Dynamics) gas / plasma non-equilibrium systems for applications in the aerospace, energy and materials science

People Involved

Francesco

Taccogna

CNR Researcher

Group Coordinator 

Domenico

Bruno

CNR Researcher

Pierpaolo

Minelli

CNR Researcher

Maria

Rutigliano

CNR Researcher

Facilities & Labs

HPC Cluster and Services @ Bari

Linee di Ricerca

Publications

  1. F. Taccogna, R. Schneider, S. Longo, M. Capitelli, Kinetic simulations of plasma thrusters, Plasma Source Sci. and Technol., 17, 024003, (2008) ISNN: 0963-0252; doi: 10.1088/0963-0252/17/2/024003
  2. F. Taccogna, S. Longo, M. Capitelli, R. Schneider, Anomalous Transport induced by Sheath Instability in Hall Effect Thrusters, Applied Physics Letters, 94, (251502), (2009) ISNN: 0003-6951; doi: 10.1063/1.3152270
  3. F. Taccogna, P. Minelli, S. Longo, M. Capitelli, R. Schneider, Modeling of a negative ion source III. Two-dimensional structure of the extraction region, Phys. Plasmas 17, 063502, (2010) ISNN: 1070-664X; doi: 10.1063/1.3431635
  4. F. Taccogna, P. Minelli, S. Longo, Three-dimensional structure of the extraction region of a hybrid negative ion source, Plasma Sources Sci. and Technol., 22, 045019, (2013) ISNN: 0963-0252; doi: 10.1088/0963-0252/22/4/045019
  5. N. Oudini, N. Sirse, F. Taccogna, A. R. Ellingboe and A. Bendib, Photo-detachment signal analysis to accurately determine electronegativity, electron temperature, and charged species density, Appl. Phys. Lett. 109, 124101 (2016); doi: 10.1063/1.4963138
  6. Maria Rutigliano, Fernando Pirani, Selectivity in the inelastic rotational scattering of hydrogen molecules from graphite, Chem. Phys., 479, 11–19, (2016), doi:10.1016/j.chemphys.2016.09.002
  7. Maria Rutigliano, Nico Sanna, Amedeo Palma, Multiple approach to model unpaired spin density effects in H-ZSM5 zeolite with extra-framework O atom: H-abstraction reaction from methane, Computational and Theoretical Chemistry, 1074, 9-18, (2015), doi: 10.1016/j.comptc.2015.10.002
  8. M. Rutigliano, P. Gamallo, R. Sayós, S. Orlandini, and M. Cacciatore, A molecular dynamics simulation of hydrogen atoms collisions on an H-preadsorbed silica surface, Plasma Sources Science and Technology, 23, 045016, (2014), doi: 10.1088/0963-0252/23/4/045016
  9. M. Rutigliano, D. Santoro, M. Balat-Pichelin, Hydrogen atom recombination on tungsten at high temperature: Experiment and Molecular Dynamics Simulation, Surface Science, 628, 66-75, (2014), doi: 10.1016/j.susc.2014.05.007
  10. Costantino Zazza, Maria Rutigliano, Nico Sanna, Vincenzo Barone, Mario Cacciatore, Oxygen Adsorption on b-Quartz Model Surfaces: Some Insights from Density Functional Theory Calculations and Semiclassical Time-Dependent Dynamics, J. Phys. Chem. A, 116, 1975−1983, (2012), doi: 10.1021/jp205517j
  11. C.M. Coppola, G. Mizzi, D. Bruno, F. Esposito, D. Galli, F. Palla, S. Longo, State-to-state vibrational kinetics of H2 and H2+ in a post-shock cooling gas with primordial composition, MNRAS, 457, 3732-3742, (2016), doi: 10.1093/mnras/stw198
  12. D. Bruno, A. Frezzotti, G.P. Ghiroldi, Oxygen transport properties estimation by classical trajectory-direct simulation Monte Carlo, Phys. Fluids, 27, 057101, (2015), doi: 10.1063/1.4921157
  13. V. Laporta, D. Bruno, Electron-vibration energy exchange models in nitrogen-containing plasma flows, J. Chem. Phys., 138, 104319, (2013), doi: 10.1063/1.4794690
  14. D. Bruno, F. Esposito, V. Giovangigli, Relaxation of rotational-vibrational energy and volume viscosity in H-H2 mixtures, J. Chem. Phys., 138, 084302, (2013), doi: 10.1063/1.4792148
  15. D. Bruno, P. Facchi, S. Longo, P. Minelli, S. Pascazio, A. Scardicchio,  Quantum Zeno Effect in a Model Multilevel Molecule, J. Phys. Chem. A, 113, 14875-14886, (2009), doi: 10.1021/jp9050512

Projects

Apulia Space
G. Colonna, Manager WP A1.6 Space Transport

Latest News

  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

  • Workshop annuale d’Istituto – II ed.

    Workshop annuale d’Istituto – II ed.

    Cetraro (CS), 3 -5 maggio 2017

    Il programma completo dell’evento – download

    La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

CeleBra – CELl Engineering BiomateRiAls

Mission
1. Development of biocompatible substrates, through soft lithography techniques, with different gradient stiffness’s and different surface coating for the control of cell motility and adhesion of cancer cells (i.e. glioblastoma)/ healthy cells and bioactive scaffolds to promote cell adhesion, proliferation and differentiation and with particular emphasis on potential applications of such materials in tissue engineering and medicine regenerative.
2. Synthesis of new smart biomaterials, by uptake in living cells of small fluorescent molecules (in collaboration with Dr. G. Barbarella, CNR-ISOF Bologna).
3. Development of new organic/inorganic delivery system for controlled release of active agents, such as drugs and gene.

People Involved

Barbara

Cortese

CNR Researcher

Group Coordinator

Ilaria Elena

Palamà

CNR Researcher

Stefania

D’Amone

 CNR Technician

Facilities & Labs

S.Li.M. Lab @Roma

BioLab @Lecce

Characterization Lab @ Lecce

Nanofab Lab @ Lecce

Research Lines

Publications

  1. Palamà IE, D’Amone S, Arcadio V, Biasiucci M, Mezzi A, Cortese B. Cell mechanotatic and cytoxic response to Zinc oxide nanorods depends on substrate stiffness. Toxicology Research, 2016, 5, 1699-1710, ISSN: 2045-4538, doi:10.1039/C6TX00274A
  2. Di Maria F, Zangoli M, Palamà IE, Fabiano E, Zanelli A, Monari M, Perinot A, Caironi M, Maiorano V, Maggiore A, Pugliese M, Salatelli E, Gigli G, Viola I, Barbarella G. Improving the property-function tuning range of thiophene materials via facile synthesis of oligo/polythiophene-S-oxides and mixed -S-oxides/-S,S-dioxides. Advanced Functional Materials, 2016, DOI: 10.1002/ adfm.201600992.
  3. Toro RG, Caschera D, Palamà IE, D’Amone S, Biasiucci M, Federici F, Gigli G, Cortese B. Unconventional patterning by Solvent-Assisted Surface-tension-driven Lithography. Journal of Colloid and Interface Science, 2015, vol. 446; p. 44-52, ISSN: 0021-9797, doi: 10.1016/j.jcis.2015.01.015
  4. Palamà IE, D’Amone S, Arcadio V, Caschera D, Toro RG, Gigli G, Cortese B. Underwater Wenzel and Cassie Oleophobic behaviour. Journal of Materials Chemistry A, 2015, vol. 3; p. 3854-3861, ISSN: 2050-7496, doi: 1039/C4TA06787H
  5. Caschera D, Toro RG, Federici F, Riccucci C, Ingo GM, Gigli G, Cortese B. Flame retardant properties of plasma pretreated/Diamond-Like Carbon (DLC) coated cotton fabrics. CELLULOSE, 2015, vol. 22; p. 2797-2809, ISSN: 0969-0239, doi: 10.1007/s10570-015-0661-8
  6. Cortese B., D’Amone S, Gigli G, Palamà IE. Sustained anti BCR-ABL activity with pH responsive Imatinib Mesylate loaded PCL nanoparticles in CML cells. Medchemcomm, 2015. vol. 6; p. 212-221, ISSN: 2040-2503, doi: 10.1039/C4MD00348A
  7. Palamà IE, Cortese B., D’Amone S, Arcadio V, Gigli G. Couple delivery of Imatinib Mesylate and Doxorubicin with nanoscaled polymeric vectors for a sustained downregulation of BCR-ABL in Chronic Myeloid Leukemia. Biomaterials Science, 2015. vol. 3; p. 361-372, ISSN: 2047-4830, doi: DOI: 10.1039/C4BM00289J
  8. Palamà IE, Cortese B, D’Amone S, Gigli G. mRNA delivery using non-viral PCL nanoparticles. Biomaterials Science, 2015, vol. 3; p. 144-151, ISSN: 2047-4830, doi: 10.1039/C4BM00242C
  9. Palamà IE, Cortese B, D’Amone S, Gigli G. Gene therapy with non-viral PCL nanoparticles. Therapeutic Delivery, 2015, vol. 6; p. 769-771, ISSN: 2041-5990, doi: 10.4155/TDE.15.41
  10. Pagani F, Paolicelli RC, Murana E, Cortese B, Di Angelantonio S, Zurolo E, Guiducci E, Ferreira TA, Garofalo S, Catalano M, D’Alessandro G, Porzia A, Peruzzi G, Mainiero F, Limatola C, Gross CT, Ragozzino D. Defective microglial development in the hippocampus of CX3CR1 deficient mice. Frontiers in Cellular Neuroscience, 2015, vol. 9; p. 111-, ISSN: 1662-5102, doi: 10.3389/fncel.2015.00111
  11. Palamà IE, Arcadio V, Cortese B, D’Amone S, Gigli G. Dexamethasone delivery with coated calcium carbonate microcubes for sustained growth of osteoblasts. Rendiconti Lincei, Scienze Fisiche e Naturali, 2015, vol. 26; p. 239-244, ISSN: 2037-4631, doi: 10.1007/s12210-015-0430-5
  12. Palamà IE, Di Maria F, D’Amone S, Barbarella G, Gigli G. Biocompatible and biodegradable fluorescent microfibers physiologically secreted by live cells upon spontaneous uptake of thiophene fluorophore. Journal of Materials Chemistry B, 2015, 3 (1), 151- 158.
  13. Cortese B, Caschera D, Federici F, Ingo GM, Gigli G. Superhydrophobic Fabrics For Oil/Water Separation through a diamond like carbon (DLC) Coating. Journal of Materials Chemistry A, 2014, vol. 2; p. 6781-6789, ISSN: 2050-7496, doi: 10.1039/C4TA00450G
  14. Cortese B., Palamà IE, D’Amone S, Gigli G. Influence of electrotaxis on cell behaviour. Integrative Biology, 2014, vol. 6; p. 817-830, ISSN: 1757-9708, doi: 10.1039/C4IB00142G
  15. Palamà IE, D’Amone S, Biasiucci M, Gigli G, Cortese B. Bioinspired Design of a Photoresponsive Superhydrophobic/oleophilic surface with Underwater Superoleophobic Efficacy. Journal of Materials Chemistry A, 2014, vol. 2; p. 17666-17675, ISSN: 2050-7496, doi: 10.1039/C4TA04068F
  16. Caschera D, Mezzi A, Cerri L, De Caro T, Riccucci C, Ingo GM, Padeletti G, Biasiucci M, Gigli G, Cortese B. Effects of Plasma treatments for improving extreme wettability behaviour of cotton fabrics. Cellulose, 2014, vol. 21; p. 741-756, ISSN: 0969-0239, doi: 10.1007/s10570-013-0123-0
  17. Di Maria F, Palamà IE, Baroncini M, Barbieri A, Bizzarri R, Gigli G, Barbarella G. Live Cell Cytoplasm Staining and Selective Labeling of Intracellular Proteins by Non-toxic Cell-permeant Thiophene Fluorophores. Organic & Biomolecular Chemistry, 2014, 12: 1603-1610.
  18. Scalera F, Gervaso F, Sanosh KP, Palamà IE, Dimida S, Sannino A. Development of a novel hybrid porous scaffold for bone tissue engineering: forsterite nanopowder reinforced chitosan. Key Engineering Materials, 2014, 587: 249-254.
  19. Palamà IE, Coluccia AML, Gigli G. Uptake of Imatinib-loaded polyelectrolyte nanocomplexes by BCR-ABL+ cells: a long-acting drug delivery strategy for targeting oncoprotein activity. Nanomedicine (London), 2014, 9 (14): 2087-2098.
  20. Caschera D, Cortese B, Mezzi A, Brucale M, Ingo G M, Gigli G, Padeletti G. Ultra hydrophobic/superhydrophilic modified cotton textiles through functionalized Diamond-Like Carbon coatings for self-cleaning applications. Langmuir, 2013 vol. 29; p. 2775-2783, ISSN: 0743-7463, doi: 10.1021/la305032k
  21. Faraldi F, Cilingirogl, A, Angelini E, Riccucci C, De Caro T, Batmaz A, Mezzi A, Caschera D, Cortese B. Micro-chemical and micro-structural investigation of archaeological bronze weapons from the Ayanis fortress (lake Van, Eastern Anatolia, Turkey). Applied Physics A, Materials Science & Processing, 2013. vol. 113; p. 911-921, ISSN: 0947-8396
  22. Cortese B, Riehle M, D’Amone S, Gigli G. Influence of Variable Substrate geometry on Wettability and Cellular Responses. Journal of Colloid and Interface Science, 2013, vol. 394; p. 582-589, ISSN: 0021-9797, doi: 10.1016/j.jcis.2012.11.051.
  23. Cortese B, Caschera D, De Caro T, Ingo GM. Micro-chemical and -morphological features of heat treated plasma sprayed Zirconia-based Thermal Barrier Coatings. 2013, Thin Solid Films, vol. 549; p. 321-329, ISSN: 0040-6090
  24. Cortese B, Caschera D, Padeletti G, Ingo G M, Gigli G. A brief review of surface functionalized cotton fabrics. Surface Innovations, 2013, vol. 1; p. 140-156, ISSN: 2050-6252, doi: 10.1680/si.13.00008
  25. Viola I, Palamà IE, Coluccia AML, Biasiucci M, Dozza B, Lucarelli E, Bettini C, Barbarella G, Gigli G. Physiological formation of fluorescent and conductive protein microfibers in live fibroblasts upon spontaneous uptake of biocompatible fluorophores. Integrative Biology, 2013, 5, 1057- 1066
  26. Palamà IE, D’Amone S, Coluccia AML, Gigli G. Micropatterned polyelectrolyte multilayer films promote alignment and myogenic differentiation of C2C12 cells in standard growth medium. Biotechnology & Bioengineering, 2013, 110 (2), 586-596.
  27. Viola I, Zacheo A, Arima V, Aricò AS, Cortese B, Manca M, Zocco A, Taurino A, Rinaldi R, Gigli G The influence of polydimethylsiloxane curing ratio on capillary pressure in microfluidic devices. Applied Surface Science, 2012, vol. 258; p. 8032-8039, ISSN: 0169-4332
  28. Cortese B, Morgan H. Controlling the Wettability of Hierarchically Structured Thermoplastics. Langmuir, 2012, vol. 28; p. 896-904, ISSN: 0743-7463, doi: 10.1021/la203741b
  29. Palamà I.E., Coluccia A.M.L., Gigli G. and Riehle M. Modulation of alignment and differentiation of skeletal myoblasts by biomimetic materials. Integrative Biology, 2012, 4, 1299-1309.
  30. Reddiconto G., Toto C., Palamà I.E., De Leo S., De Luca E, De Matteis S., Dini L., Sanapo F., Gambacorti Passerini C., Di Renzo N., Maffia M., Coluccia A.M.L. Targeting of GSK3beta promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors preserving normal stem cells., Blood, 2012, 119 (10), 2335-2345.
  31. Palamà I.E., D’Amone S., Coluccia A.M.L., Biasiucci M. and Gigli G. Cell self-patterning on uniform PDMS-surface with controlled mechanical cues. Integrative Biology, 2012, 4, 228-236 (Highlight: the paper is the 5th position of the “top ten most accessed articles” of Integrative Biology web site in the month of December 2011, http://blogs.rsc.org/ib/page/13/).
  32. Cortese B., Mowlem M. C., Morgan H. Characterisation of an Irreversible Bonding Process for COC-COC and COC-PDMS-COC Sandwich Structures and Application to Microvalves. Sensors And Actuators B, Chemicals, 2011, vol. 160; p. 1473-1480, ISSN: 0925-4005, doi: 10.1016/j.snb.2011.07.040
  33. Ogilvie R G, Sieben V J, Cortese B., Mowlem M C, Morgan H.. Chemically resistant microfluidic valves from Viton® membranes bonded to COC and PMMA. Lab on a Chip, 2011, vol. 11; p. 2455-2459, ISSN: 1473-0189, doi: 10.1039/C1LC20069K
  34. Palamà I.E., Di Maria F., Viola I., Fabiano E., Gigli G., Bettini C. and Barbarella G. Live-cell-permeant thiophene fluorophores and cell-mediated formation of fluorescent fibrils.. Journal of the American Chemical Society (JACS), 2011, 133, 17777–17785.
  35. Palamà I.E, Musarò M., Coluccia A.M.L., D’Amone S. and Gigli G. Cell uptake and validation of novel PECs for biomedical applications.. Journal of Drug Delivery, 2011, 1-7.
  36. Athanassiou A, Cingolani R, Caputo G, Cortese B., Gigli G, Nobile C, P Cozzoli D. Reversible wettability of hybrid organic/inorganic surfaces of systems upon light irradiation/storage cycles. International Journal of Nanomanufacturing, 2010, vol. 6; p. 312-323, ISSN: 1746-9392, doi: 10.1504/IJNM.2010.034793
  37. Coluccia A.M.L., De Leo S., De Luca E., Reddiconto G., Palamà I.E., Redaelli S., De Matteis S., Gambacorti-Passarini C., Dini L. and Maffia M. Deregulated Activity and Localization of Glycogen Synthase Kinase 3 beta In Chronic Myeloid Leukemia Progenitors: Role In Leukemia Maintenance and Targeted Therapy.. Blood, 2010, 21, 521.
  38. Palamà I.E., Leporatti S., De Luca E., Gambacorti-Passerini C., Di Renzo N., Maffia M., Rinaldi R., Gigli G., Cingolani R. and Coluccia A.M.L. Imatinib-Loaded polyelectrolyte microcapsules for sustained targeting of BCR-ABL+ leukemia stem cells.. Nanomedicine, 2010, 5 (3), 419-431.
  39. Palamà I.E., Coluccia A.M.L., Della Torre A., Vergaro V., Perrone E., Cingolani R., Rinaldi R. and Leporatti S. Multilayered Polyelectrolyte Capsules and Coated Colloids: Cytotoxicity and Uptake by Cancer Cells. Science of Advanced Materials, 2010, 2, 1-9.
  40. Blasi L., Argentiere S., Morello G., Palamà I.E., Barbarella G., Cingolani R, Gigli G. Uptake and distribution of labeled antibodies into pH-sensitive microgels. Acta Biomaterials, 2010, 6, 2148-2156
  41. Cortese B., Gigli G, Riehle M. Mechanical Gradient Cues for Guided Cell Motility and Control of Cell Behaviour on uniform substrates. Advanced Funcional Materials, (2009), vol. 19; p. 2961-2968, ISSN: 1616-301X, doi: 10.1002/adfm.200900918
  42. Cortese B., Piliego C, Viola I, D’Amone S, Cingolani R, Gigli G. Engineering transfer of micro and nanometer scale features by surface energy modification. Langmiur, 2009. vol. 25; p. 7025-7031, ISSN: 0743-7463, doi: 10.1021/la900248j
  43. Caputo G, Cortese B., Nobile C, Salerno M, Cingolani R, Gigli G, Cozzoli PD, Athanassiou. A Reversibly Light-Switchable Wettability of Hybrid Organic/Inorganic Surfaces With Dual Micro-/Nanoscale Roughness. Advanced Functional Materials, 2009. vol. 19; p. 1149-1157, ISSN: 1616-301X, doi: 10.1002/adfm.200800909
  44. Cortese B., Gigli G, Riehle M. Mechanical guidance cues for control of cell motility and determination of traction forces. Biomaterialien, 2009, vol. 10, ISSN: 1616-0177
  45. Cortese B., Riehle M, D’Amone S, Gigli G. Advances in micro-fabrication: from 2D to 3D PDMS scaffolds for tissue engineering applications. European Cells & Materials, 2009, vol. 18; p. 55-, ISSN: 1473-2262
  46. Cortese B., D’Amone S, Manca M, Viola I, Cingolani R, G. Gigli. Superhydrophobicity due to the hierarchical scale roughness of PDMS surfaces. Langmuir, 2008, vol. 24; p. 2712-2718, ISSN: 0743-7463, doi: 10.1021/la702764x
  47. Manca M, Cortese B., Viola I, Arico AS, Cingolani R, G. Gigli. Influence of chemistry and topology effects on superhydrophobic CF4-plasma-treated poly(dimethylsiloxane) (PDMS). Langmuir, 2008, vol. 24; p. 1833-1843, ISSN: 0743-7463
  48. Cortese B., Riehle M, Cingolani R, Gigli G. Cells response sensing durotaxis by varying mechanical rigidity. European cells & Materials, 2008, vol. 16; p. 44-44, ISSN: 1473-2262
  49. Piliego C, Mazzeo M, Cortese B., Cingolani R, G. Gigli. Organic light emitting diodes with highly conductive micropatterned polymer anodes. Organic Electronics, 2008, vol. 9; p. 401-406, ISSN: 1566-1199, doi: 10.1016/j.orgel.2007.12.007
  50. Viola I., Pisignano D., D’Amone S., Cingolani R. and Gigli G. In-situ monitoring of viscoelastic liquid in a microfluidic enviroment.; Synthetic Metals, 2005.
  51. Rizzo A., Mazzeo M., Palumbo M., Lerario G., D’Amone S., Cingolani R., and Gigli G. Hybrid Light Emitting Diodes by ?-CP Double Transfer of Colloidal Semiconductor CdSe/ZnS Quantum Dots on Organic Layers., Advanced Materials, 2008.
  52. Viola I., Mazzeo M, Passabì A., D’Amone S., Cingolani R. and Gigli G. Organic Light Emitting Pixel Arrays by Supra-molecular Self-organization,; Proc. SPIE, 2005, vol. 5838: 29-37, Nanotechnology II.
  53. Viola I., Mazzeo M., Passabì A., D’Amone S., Cingolani R. and Gigli G. Positive/Negative Arrays of Organic Light-Emitting Diodes by a Surface-Tension-Driven Approach, Advanced Materials, 2005, 17(24): 2935-2939.
  54. Pisignano D., D’Amone S., Gigli G. and Cingolani R. Rigid organic molds for nanoimprinting lithography by replica molding of high glass transition temperature polymers, Journal of Vacum Science and Technology, 2004, B 22 (4): 1759-1763.

Book Chapter

Strategies and applications for incorporating physical and chemical modifications for functional Cellulose based materials. Barbara Cortese, Ilaria Elena Palamà, Stefania D’Amone, and Giuseppe Gigli. Cellulose and Cellulose Derivatives: Synthesis, Modification, Nanostructure and Applications. HAUPPAUGE NY 11788-3619: Nova Science Publishers, Inc., 2015 – ISBN: 978-1-63483-571-8, Chapter 2: 35 – 65  (Invited chapter).

Mechanical guidance of cell migration. Ilaria Elena Palamà, Stefania D’Amone, Barbara Cortese. Nanomaterials and Regenerative Medicine. IAPC Publishing, Zagreb, Croatia, 2016 – ISBN: 978-953-56942-3-6, Chapter 22: 563 – 580 (Invited chapter)

Patent

Cancer Therapy with Silver Nanoparticles. I.E. Palamà, M. Pollini, F. Paladini, G. Accorsi, A. Sannino and G. Gigli. US 4182.3000. 2013 and WO 3000. 2014.

Abstract: A novel approach in cancer therapy based on the cytotoxic effect of silver nanoparticles on cancer cells, without any deleterious effect on normal cells, has been developed.

Projects

My First AIRC Grant – Role of Electro/Mechanical cues in the control and guidance of Glioma Progression (MFAG)  2015 n. 16803 (2015-2018)_ Principal Investigator: Barbara Cortese

Latest News

  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

  • Workshop annuale d’Istituto – II ed.

    Workshop annuale d’Istituto – II ed.

    Cetraro (CS), 3 -5 maggio 2017

    Il programma completo dell’evento – download

    La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

Photonics & Optoelectronics

The investigation of frontier physics mainly related to the interactions and coupling of light with matter both from a macroscopic point of view as well as at the single particle level. Collective coherent phenomena of condensates of Bose Einstein are studied in semiconductor materials exploiting quasiparticles generated by the strong coupling between light and excited states of matter to unravel a rich phenomenology of quantum fluids under superfluid or supersonic regimes, exploring the dynamics of vortex states, optically driven non-equilibrium condensates and the expanding or trapping of quantum gases. Other fields of interest are correlation of quantum states, and highly confined plasmon-polariton fields. Inorganic semiconductors and organic materials are investigated from a fundamental point of view as well as for new applicative concepts, like all-optical transistors, switches and logical gates.

Organic Random Lasers

Random Lasers (RLs) are realized in disordered media with gain; the feedback for stimulated emission of light is given by the scattering and no external cavity is needed…

Latest News

  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

  • Workshop annuale d’Istituto – II ed.

    Workshop annuale d’Istituto – II ed.

    Cetraro (CS), 3 -5 maggio 2017

    Il programma completo dell’evento – download

    La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

Modeling, Theory and Computation

Our research focuses on: 1. the theoretical and computational study of systems with many interacting constituents, from glasses and spin glasses to soft and biological matter; 2. the physics of random lasing materials; 3. nonlinear, turbulent and complex flows; 4. the quantitative and computational analysis of biological systems, from single-molecules to biological networks and system-level properties.
In addition, we are interested in the development of efficient algorithms for inference and big data analysis.

Complex Flows And Nonlinear Time Analysis

The experimental study of nonlinear and complex systems relies on the design of specific advanced data analysis tools, which need to be able to identify properties of the dynamics…

Computational Biology

Theoretical methods and mathematical modeling can be applied to investigate complex physical systems that are found in biological organisms. Computer simulations are a common tool to analyze the interactions…

Photonics in Random Media

In recent years, random lasing materials (e.g. powders, porous media, precipitates in solution, or photonic crystals with impurities) have been extensively studied…

Scientific Computing & Big Data

We exploit parallel computing on single and multi Graphic Processing Units (GPU’s) for several problems. In particular, we develop optimised parallel codes for continuous…

Statistical Mechanics

We study disordered and frustrated systems such as spin-glasses, structural glasses and random photonics models by means of advanced methods in statistical mechanical of disordered…

Turbulence in Plasmas

Turbulence is an ubiquitous phenomenon that can be observed on a huge range of scales, from galaxy clusters down to micro- and nano-fluidics. It is observed mostly in neutral flows…

Latest News

  • Zeiss Microscopy Technology and Complete Correlative Workflow

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program – PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

  • MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 – 27 June 2017

    Program – MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

  • Workshop annuale d’Istituto – II ed.

    Workshop annuale d’Istituto – II ed.

    Cetraro (CS), 3 -5 maggio 2017

    Il programma completo dell’evento – download

    La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

Job Openings

    Nano-Biotechnology

    Nano-biotechnology aims at the development of nanotechnology-based tools for biomedical applications. The bottom-up and top-down approaches, typical of nanotechnology, applied to biology and biochemistry lead to the development of nanostructured materials and devices to improve several fields of current biomedical research like Biomolecular Delivery, advanced and high resolution Imaging and Regenerative Medicine. Nanotechnology investigation tools of materials and surfaces applied to biology increase the basic knowledge ofself-assembly of biomolecules (as described in Biointerfaces) and of cellular mechanisms (Cell Biology). In the view of providing “point-of-care” diagnostic toolsand state-of-the–art approaches towards personalized medicine,microscale devicesare developedas described in the sections Lab on Chip and Biosensors & Bioelectronics. Nano-biotechnological applications are supported by the Modeling, Theory and Computation reported in the section Computational Biology.

    Biomolecular Delivery

    The major goal in designing nanosystems as drug delivery vectors is to control the release of pharmacologically active agents and to achieve the site-specific action of drugs at a therapeutically optimal rate and dosage regimen…

    Cell biology

    The research activities of this area at the cross-roads of materials science, nanotechnology and cell biology, primarily focusing on how newly-discovered materials and interfacial processes can be developed and used for specific applications…

    Imaging

    At NANOTEC several high resolution techniques are available for fine imaging of biomolecules, living cells and tissue. Mainly we focus on engineering of high-resolution molecular and semiconductor-based tools for fine fluorescence imaging…

    Regenerative medicine

    Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating cells, tissues or organs to restore or establish normal function…

    Lab on chip (LOC)

    The Lab on a Chip (LOC) family is wide and multifaced due to the large number of possible applications ranging from the biomedical to the agrifood and environmental fields….

    Latest News

    • Zeiss Microscopy Technology and Complete Correlative Workflow

      Zeiss Microscopy Technology and Complete Correlative Workflow

      Lecce, Italy, 2017 Wednesday July 19th 

      CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

      Program – PDF

      Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

    • MCS 2017

      International Workshop on Micropropulsion and CubeSats

      Bari, Italy, 26 – 27 June 2017

      Program – MSC2017

      This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

    • Workshop annuale d’Istituto – II ed.

      Workshop annuale d’Istituto – II ed.

      Cetraro (CS), 3 -5 maggio 2017

      Il programma completo dell’evento – download

      La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

    Scientific Computing & Big Data

    We exploit parallel computing on single and multi Graphic Processing Units (GPU’s) for several problems. In particular, we develop optimised parallel codes for continuous variables Monte Carlo dynamics, Population dynamics for Belief propagation and Cavity method in random graphs, and Pseudolikelihood maximisation.

     

    Algorithms. We are interested in the development of efficient computational techniques for the study of inference and optimization problems in large experimental data bases, mostly for complex biological systems. Among the key application domains are the analysis of gene expression at single cell resolution, the study of kinetic and/or thermodynamical conservation laws in cellular metabolic networks, the analysis of evolutionary variability in protein sequences, the characterization of cell-to-cell variability in microbial populations (at both the physiological and the molecular level), and the inference of complex interaction networks (protein-protein, protein-DNA, RNA-RNA) from genomic and/or thermodynamic data. In addition, we work on the development of multi-scale models for metabolic engineering of unicellular organisms and large-scale simulation of human tissues.

     

    Biophysical simulations: Molecular competition on receptors. Many biological processes are based on the interaction between a receptor and various partner molecules that can bind it. To clarify these interactions, ‘in vitro’ experiments usually analyze the receptor in the presence of another single molecule. Nevertheless, ‘in vivo’ mechanisms are much more complex, and there can be competition phenomena among different molecular partners for the same receptor, or among different molecules of the same type that could associate to distinct regions of the same receptors through various binding modes. Computer simulations can help in a systematical mapping of the various possible combinations.

    Facilities and Labs

    S.Li.M. Lab @ Roma

    People

    Andrea_DeMArtinoAndrea

    De Martino

    CNR Researcher

    Bruno_RizzutiBruno

    Rizzuti

    CNR Researcher

    leuzziLuca

    Leuzzi

    CNR Researcher

    fabrizioantenucci_postdocFabrizio

    Antenucci

    Associate PostDoc

    alessiamarruzzo_postdocAlessia

    Marruzzo

    Associate PostDoc

    Publications

    1. S. Evoli, D.L. Mobley, R. Guzzi, B. Rizzuti, Multiple binding modes of ibuprofen in human serum albumin identified by absolute binding free energy calculations, bioRxiv, 8, 1-27, (2016) doi:10.1101/068502.
    2. Regularization and decimation pseudolikelihood approaches to statistical inference in XY-spin models, P Tyagi, A Marruzzo, A Pagnani, F Antenucci, L Leuzzi, Physical Review B 94, 024203 (2016), Doi: 10.1103/PhysRevB.94.024203.
    3.  Multi-body quenched disordered XY and p-clock models on random graphs. A Marruzzo, L Leuzzi, Physical Review B 93, 094206 (2016) Doi: 10.1103/PhysRevB.93.094206.
    4.  M Mori, T Hwa, OC Martin, A De Martino and E Marinari. Constrained Allocation Flux Balance Anal- ysis. PLoS Comp Biol 12:e1004913 (2016) Doi: 10.1371/journal.pcbi.1004913
    5. A Martirosyan, M Figliuzzi, E Marinari and A De Martino. Probing the limits to microRNA-mediated control of gene expression. PLoS Comp Biol 12: e1004715 (2016) Doi: 10.1371/journal.pcbi.1004715
    6. Nonlinear XY and p-clock models on sparse random graphs: Mode-locking transition of localized waves, A Marruzzo, L Leuzzi, Physical Review B 91, 054201 (2015) Doi: 10.1103/PhysRevB.91.054201
    7. Statistical mechanical theory of mode-locked multimode lasers in closed cavity: determination of thresholds, spectra, pulse phase delays and pulse correlations. F Antenucci, M Ibanez Berganza, L Leuzzi, Phys. Rev. A 91, 043811 (2014) Doi:.10.1103/PhysRevA.91.043811
    8. D De Martino, F Capuani and A De Martino. Inferring metabolic phenotypes from the exometabolome through a thermodynamic variational principle. New J Phys 16: 115018 (2014) Doi: 10.1088/1367-2630/16/11/115018
    9. A De Martino, D De Martino, R Mulet and A Pagnani. Identifying all moiety conservation laws in genome-scale metabolic networks, PLoS ONE 9:e100750  (2014)  Doi: 10.1371/journal.pone.0100750
    10. A Seganti, F Ricci Tersenghi and A De Martino. Searching for feasible stationary states in reaction net- works by solving a Boolean constraint satisfaction problem. Phys Rev E 89:022139 (2014) Doi: 10.1103/PhysRevE.89.022139

    Other selected publications

    1. FA Massucci, M DiNuzzo, F Giove, B Maraviglia, I Perez Castillo, E Marinari and A De Martino. Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective. BMC Sys Biol 7:103 (2013) Doi: 10.1186/1752-0509-7-103
    2. D De Martino, F Capuani, M Mori, A De Martino and E Marinari. Counting and correcting thermody- namically infeasible flux cycles in genome-scale metabolic networks. Metabolites 3:946 (2013) Doi: 10.3390/metabo3040946
    3. FA Massucci, F Font Clos, A De Martino and I Perez Castillo. A novel methodology to estimate metabolic flux distributions in constraint-based models. Metabolites 3:838 (2013) Doi: 10.3390/metabo3030838
    4. A Seganti, A De Martino and F Ricci Tersenghi. Boolean constraint satisfaction problems for reaction networks. J Stat Mech P09009 (2013) Doi:10.1088/1742-5468/2013/09/P09009
    5. D De Martino, M Figliuzzi, A De Martino and E Marinari. A scalable algorithm to explore the Gibbs energy landscape of genome-scale metabolic networks. PLoS Comp Biol 8:e1002562 (2012) Doi: 10.1371/journal.pcbi.1002562

    Latest News

    Zeiss Microscopy Technology and Complete Correlative Workflow

    [vc_row][vc_column][vc_column_text]

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program - PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

    [/vc_column_text][/vc_column][/vc_row]

    MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 - 27 June 2017

    Program - MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

    Workshop annuale d'Istituto - II ed.

    Workshop annuale d'Istituto - II ed.

    Cetraro (CS), 3 -5 maggio 2017

    Il programma completo dell'evento - download

    La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

    Turbulence in Plasmas

    Turbulence is an ubiquitous phenomenon that can be observed on a huge range of scales, from galaxy clusters down to micro- and nano-fluidics. It is observed mostly in neutral flows, but also in charged, magnetized flows such as astrophysical plasmas. The study of turbulence requires a multiple approach: theoretical, experimental, based on data analysis and on numerical simulations. All these aspects are exploited here, with particular focus on space and laboratory turbulent plasmas.

    Most of the visible matter in the universe is in the state of plasma. Often times, astrophysical plasmas have highly turbulent dynamics, resulting in a large number of interesting processes such as: energy dissipation, particle acceleration, excitation of electromagnetic waves, particle heating, magnetic reconnection, formation of shocks. All these phenomena can be studied in-situ only in space plasma, where instruments on-board scientific space missions can take measurements. Data can be studied using specific diagnostic tools, which allow the validation of theories and models. A substantial use of numerical simulations is also necessary. The study of turbulence in the interplanetary space is therefore of broad interest for the understanding of the dynamics of astrophysical plasmas, but also for its implications on laboratory plasmas and for the Sun-Earth interaction.

    The study of space plasmas turbulence is based on three main approaches: the analysis of data provided by the scientific mission; the development of theoretical models and novel data analysis techniques; the use of numerical simulations (massive computational resources are often required; these are provided by large facilities for high performance computing, such as CINECA, or the UNICAL HPCC. Examples are the full characterization of intermittency in solar wind turbulence [Sorriso-Valvo et al. 1999; 2015], and the validation of the theoretical prediction for the scaling law of the energy flux in solar wind turbulence [Sorriso-Valvo et al., 2007].

    Facilities & Labs

    S.Li.M. Lab @ Roma

    People

    Luca_Sorriso_valvoLuca

    Sorriso-Valvo

    CNR Researcher

    Publications

    1. Bruno, D. Telloni, L. Primavera, E. Pietropaolo, R. D’Amicis, L. Sorriso-Valvo, V. Carbone, F. Malara and P. Veltri, Radial evolution of intermitency of density fluctuations in the fast solar wind, The Astrophysical Journal 786, 53 (2014), DOI: 10.1088/0004-637X/786/1/53.
    2. H. K. Chen, L. Sorriso-Valvo, J. Safrankova, Z. Nemecek, Intermittency of solar wind density fluctuations from ion to electron scales,  The Astrophysical Journal Letter 789, L8 (2014), DOI: 10.1088/2041-8205/789/1/L8.
    3. De Vita, L. Sorriso-Valvo, F. Valentini, S. Servidio, L. Primavera, V. Carbone and P. Veltri, Analysis of cancellation exponents in two-dimensional Vlasov turbulence, Physics of Plasmas 21, 072315 (2014), DOI: 10.1063/1.4891339.
    4. Sorriso-Valvo, G. De Vita, M. Kazachenko, S. Krucker, L. Primavera, S. Servidio, A. Vecchio, B. Welsch, G. Fisher, F. Lepreti, V. Carbone, Sign singularity and flares in solar active region NOAA 11158, The Astrophysical Journal 801, 36 (2015), DOI: 10.1063/1.4891339
    5. Yordanova, S. Perri, L. Sorriso-Valvo and V. Carbone, Multipoint observation of anisotropy and intermittency in solar-wind turbulence, EPL 110, 19001 (2015), DOI: 10.1209/0295-5075/110/19001.
    6. Chasapis, A. Retinò, F. Sahraoui, A. Vaivads, Y. Khotyaintsev, D. Sundkvist, A. Greco, L. Sorriso-Valvo, P. Canu, Thin current sheets and associated electron heating in turbulent space plasma, The Astrophysical Journal Letters 804, L1 (2015), DOI: 10.1088/2041-8205/804/1/L1.
    7. Sorriso-Valvo, R. Marino, L. Lijoi, S. Perri and V. Carbone, Self-consistent Castaing distribution of solar wind turbulent fluctuations, The Astrophysical Journal, 807, 86 (2015), DOI: 10.1088/0004-637X/807/1/86.
    8. De Vita, A. Vecchio, L. Sorriso-Valvo, C. Briand, L. Primavera, S. Servidio, F. Lepreti and V. Carbone, Journal of Space Weather and Space Climate, 5, A28 (2015), DOI: 10.1051/swsc/2015029.
    9. Rossi, F. Califano, A. Retinò, L. Sorriso-Valvo, P. Henri, S. Servidio, F. Valentini, A. Chasapis, and L. Rezeau, Two-fluid numerical simulations of turbulence inside Kelvin-Helmholtz vortices: intermittency and reconnecting current sheets, Physics of Plasmas, 22, 122303 (2015), DOI: 10.1063/1.4936795.
    10. Leonardis, L. Sorriso-Valvo, F. Valentini, S. Servidio, F. Carbone and P. Veltri, Multifractal scaling and intermittency in hybrid Vlasov-Maxwell simulations of plasma turbulence, Physics of Plasmas, 23, 022307 (2016), DOI: 10.1063/1.4942417.
    11. Pucci, F. Malara, S. Perri, G. Zimbardo, L. Sorriso-Valvo and F. Valentini, Energetic particle transport in the presence of magnetic turbulence: influence of spectral extension and intermittency, Month. Notes R. Astron. Soc. 459, 3395 (2016), DOI: 10.1093/mnras/stw877.
    12. Vaivads et al., Turbulence Heating ObserveR – satellite mission proposal, J. Plasma Phys. 82, 905820501 (2016), DOI: 10.1017/S0022377816000775.

    Other selected publications

    1. Sorriso-Valvo, V. Carbone, P. Veltri, G. Consolini, R. Bruno, Intermittency in the solar wind turbulence through probability distribution functions of fluctuations, Geophysical Research Letters 26, 1801-1804 (1999), DOI: 10.1029/1999GL900270.
    2. Carbone, L. Sorriso-Valvo, E. Martines, V. Antoni, P. Veltri, Intermittency and turbulence in a magnetically confined fusion plasma, Physical Review E 62, R49-R52 (2000), DOI: 10.1103/PhysRevE.62.R49.
    3. Sorriso-Valvo, R. Marino, V. Carbone, A. Noullez, F. Lepreti., P. Veltri, R. Bruno, B. Bavassano, Pietropaolo E., Observation of Inertial Energy Cascade in Interplanetary Space Plasma, Physical Review Letters 99, 115001-1-115001-4 (2007), DOI:             10.1103/PhysRevLett.99.115001.
    4. Alexandrova, V. Carbone, P. Veltri, L. Sorriso-Valvo, Small-scale energy cascade of the solar wind turbulence, The Astrophysical Journal 674, 1153-1157 (2008), DOI: 10.1086/524056.
    5. Carbone, R. Marino, L. Sorriso-Valvo, A. Noullez, R. Bruno, Scaling laws of turbulence and heating of fast solar wind: the role of density fluctuations, Physical Review Letters 103, 061102 (2009), DOI: 10.1103/PhysRevLett.103.061102.
    6. Zimbardo, A. Greco, L. Sorriso-Valvo, S. Perri, Z. Voros, G. Aburjania, K. Chargazia, O. Alexandrova, Magnetic Turbulence in the Geospace Environment, Space Science Reviews 156, 89 (2010), DOI: 10.1007/s11214-010-9692-5.
    7. Perri, V. Carbone, A. Vecchio, R. Bruno, H. Korth, T. H. Zurbuchen, L. Sorriso-Valvo, Phase-ynchronization, Energy Cascade, and Intermittency in Solar-Wind Turbulence, Physical Review Letters 109, 245004 (2012), DOI: 10.1103/PhysRevLett.109.245004
    8. Dudok de Wit, O. Alexandrova, I. Furno, L. Sorriso-Valvo, G. Zimbardo, Methods for Characterising Microphysical Processes in Plasmas, Space Science Reviews 178, 693 (2013), DOI: 10.1007/978-1-4899-7413-6_21
    9. Alexandrova, C. H. K. Chen, L. Sorriso-Valvo, T. Horbury, S. D. Bale,    Solar Wind Turbulence and the Role of Ion Instabilities, Space Science Reviews 178, 101, (2013), DOI: 10.1007/s11214-013-0004-8
    10. Maruca, S. D. Bale, L. Sorriso-Valvo, J. C. Kasper, M. L. Stevens, Collisional Thermalization of Hydrogen and Helium in Solar-Wind Plasma, Physical Review Letters 111, 241101 (2013), DOI: 10.1103/PhysRevLett.111.241101.

    Project

    Turboplasmas: FP7 European Marie Curie IRSES 2010-269297 , (2011-2014)

    Anisotropy and intermittency in solar wind turbulence: ISSI Team, (2014-2015)

    Kinetic Turbulence and Heating in the Solar Wind: ISSI Team (2013-2014)

    Latest News

    Zeiss Microscopy Technology and Complete Correlative Workflow

    [vc_row][vc_column][vc_column_text]

    Zeiss Microscopy Technology and Complete Correlative Workflow

    Lecce, Italy, 2017 Wednesday July 19th 

    CNR NANOTEC @ Lecce, Aula Seminari – pal. G, Piano Terra

    Program - PDF

    Zeiss, as microscopy technology leader, provides the unique complete imaging solution ranging from light, confocal, electron, ion and Xray modalities with a complete and straightforward correlative workflow. An overview of different technologies will be presented with a special focus on X-Rray microscopy.

    [/vc_column_text][/vc_column][/vc_row]

    MCS 2017

    International Workshop on Micropropulsion and CubeSats

    Bari, Italy, 26 - 27 June 2017

    Program - MSC2017

    This narrow-field, invited-only meeting is the first attempt to bring together the Materials and Micropropulsion communities with a view to contribute to the development of the Global Materials and Micropropulsion Roadmap, and set such meetings to a regular basis.

    Workshop annuale d'Istituto - II ed.

    Workshop annuale d'Istituto - II ed.

    Cetraro (CS), 3 -5 maggio 2017

    Il programma completo dell'evento - download

    La tre giorni dedicata ai risultati di ricerca conseguiti e alle strategie scientifiche da intraprendere nel prossimo futuro.

    Computational Biology

    Theoretical methods and mathematical modeling can be applied to investigate complex physical systems that are found in biological organisms. Computer simulations are a common tool to analyze the interactions of biological structures at the molecular level, or the connections among different subsystems in large-scale networks, which are crucial to understand the basic mechanisms in the proteomics and metabolomics fields

    compiutationalbiology

    Ligand binding. Receptor-ligand interactions are responsible of molecular recognition, binding, transport and release. These mechanisms are fundamental in many processes that are vital in any living organism, and can be exploited in several applications of nanotechnology. Molecular dynamics simulations and docking calculations are theoretical tools that allow us to determine a model of interaction between a receptor and a variety of ligands. These computational techniques are useful to predict structural and dynamic properties that determine the functionality of a molecular complex between transport proteins and small compounds, such as ligands of pharmaceutical interest.

    ligandbinding

    Protein folding. Proteins are molecular ‘nanomachines’ that acquire their tridimensional structure through a spontaneous process of folding. This phenomenon is central for some of the basic mechanisms of life. Furthermore, their competitive processes (unfolding and misfolding) lead to a loss of function and are correlated to some serious pathologies. Protein folding is an intrinsically complex molecular process that needs to be investigated with a combined theoretical and experimental approach. Molecular dynamics simulations and other computational methods are able to reveal crucial details of the folding reaction.

    proteinfolding

    Regulatory RNA. Overcoming the decades’ old view according to which they are mere intermediates between DNA and proteins in the central dogma of molecular biology, RNAs are increasingly recognized for the remarkable variety of functional roles they play in eukaryotic gene expression. Non-coding RNAs (ncRNAs), in particular, are deeply involved in developmental programs and disease, to the point of having become targets of novel therapeutic approaches that aim at either inhibiting or enhancing their functionality. Importantly, most ncRNAs act by protein-mediated binding to other nucleic acids, leading to complex inter-dependencies be- tween coding and ncRNAs, RNA-binding proteins and DNA. Their central role in regulation is perhaps best exemplified by microRNAs (miRNAs), small ncRNAs of 20–25 nucleotides (nt) that mediate post-transcriptional regulation (PTR) via gene expression silencing in animals. miRNAs are believed to affect the expression of about two-thirds of protein-coding genes in humans. Their apparent ubiquity, together with the strong topological heterogeneities that characterize the PTR network that maps out the known interactions between miRNAs and other RNA species (such as mRNAs), has lead to the idea that competition for shared miRNAs can cause an effective positive interaction between different transcripts, currently referred to as the ‘ceRNA effect’. In this context, we are interested in quantifying the role and effectiveness of miRNA-mediated RNA cross-talk, with the goal of clarifying (i) under which conditions it outperforms other regulatory mechanisms, for instance in processing gene expression noise; (b) whether it can carry a significant systemic role; and (c) its relevance in specific biological cases of differentiation and disease.

     

    Cell growth and its biosynthetic costs. The coupling between the physiology of cell growth and cellular composition has been actively investigated since the 1940s. In exponentially growing bacteria, such interdependence is best expressed in a quantitative way by the bacterial ‘growth laws’ that directly relate the protein, DNA and RNA content of a cell to the growth rate. Many such laws have been experimentally characterized and many more are currently being probed at increasingly high resolution. The emerging scenario suggests that proteome organization in bacteria is actively regulated in response to the growth conditions. Several phenomenological models explain the origin of different growth laws at coarse-grained levels. By contrast, genome-scale approaches probing such relationships at the molecular level are far less developed. We have developed a mathematical modeling scheme called Constrained Allocation Flux Balance Analysis or CAFBA, in which the costs of gene expression are accounted for effectively through a single global constraint on metabolic fluxes, encodeing for the relative adjustment of proteome sectors at different growth rates. Using bacteria as the initial model organisms, we are interested in quantifying the trade-off between cell growth and its associated biosynthetic costs, generating testable predictions about the way in which the usage of metabolic pathways and protein expression levels are modulated by the growth conditions.

     

    Cell-to-cell variability in exponentially growing bacteria. Current experimental techniques (see e.g. the ‘mother machine’) can probe physiological variability by characterizing e.g. growth rate distributions for bacterial populations at single cell resolution. These distributions reflect noise at various levels, from intracellular stochasticity in gene expression and metabolite levels to fluctuations in the extracellular medium. However, upon controlling the latter, they provide a window to analyze the role of noise in the genotype-phenotype relationship. Straightforward sam- pling of the feasible space predicted by mathematical models, however, does not explain the observed statistics. We are therefore interested in identifying a physical or biological principle that drives the selection of observed growth states and hence shed light on the origin of the observed phenotypic diversity.

    People

    Andrea_DeMArtinoAndrea

    De Martino

    CNR Researcher

    Viso_UomoEnzo

    Marinari

    Full Professor

    Bruno_RizzutiBruno

    Rizzuti

    CNR Researcher

    Facilities and Labs

    S.Li.M. Lab @ Roma

    Publications

    1. M Mori et al. Constrained Allocation Flux Balance Analysis, PLOS Comp Biol 12:e1004913 (2016). DOI:10.1371/journal.pcbi.1004913
    2. D De Martino et al, Growth against entropy in bacterial metabolism: the phenotypic trade-off behind empirical growth rate distributions in E. coli, Phys Biol 13:036005 (2016). DOI:1088/1478-3975/13/3/036005
    3. S Grigolon et al, Noise Processing by MicroRNA-Mediated Circuits: the Incoherent Feed-Forward Loop, Revisited, Heliyon 2:e00095 (2016). DOI:  1016/j.heliyon.2016.e00095
    4. Martirosyan A et al, Probing the Limits to MicroRNA-Mediated Control of Gene Expression, PLOS Comp Biol 12(1): e1004715 (2016). DOI: 10.1371/journal.pcbi.1004715
    5. Evoli, L. Mobley, R. Guzzi, B. Rizzuti, Multiple   binding modes of ibuprofen in human serum albumin identified by absolute binding free energy calculations,    bioRxiv, 8, 1-27, (2016) doi:10.1101/068502
    6. Neira, B. Rizzuti, J. L. Iovanna, Determinants of the pKa values of ionizable residues in an intrinsically disordered protein, Archives of Biochemistry and Biophysics, 595, 1-16, (2016) doi: 10.1016/j.abb.2016.03.034
    7. Capuani F et al, Quantitative constraint based computational model of tumor-to-stroma coupling via lactate shuttle, Sci Rep 5:11880 (2015). DOI: 10.1038/srep11880
    8. Rizzuti, R. Bartucci, L. Sportelli, R. Guzzi, Fatty acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation, Archives of Biochemistry and Biophysics, 579, 18-25, (2015) doi: 1016/j.abb.2015.05.018
    9. Evoli, R. Guzzi, B. Rizzuti, Molecular simulations of ß-lactoglobulin complexed with fatty acids reveal the structural basis of ligand affinity to internal and possible external binding sites, Proteins: Structure, Function, and Bioinformatics, 82, 2609-2619, (2014)     doi: 1002/prot.24625
    10. Pantusa, R. Bartucci, B. Rizzuti, Stability of trans-resveratrol associated with transport proteins, Journal of Agricultural and Food Chemistry, 62, 4384-4391, (2014) doi: 1021/jf405584a
    11. D De Martino et al. Inferring metabolic phenotypes from the exometabolome through a thermodynamic variational principle. New J Phys 16: 115018 (2014). DOI:  1088/1367-2630/16/11/115018
    12. M Figliuzzi et al, RNA based regulation: dynamics and response to perturbations of competing RNAs. Biophys J 107:1011 (2014). DOI: 1016/j.bpj.2014.06.035
    13. A De Martino et al, Identifying all moiety conservation laws in genome-scale metabolic networks. PLOS ONE 9:e100750 (2014). DOI: 10.1371/journal.pone.0100750
    14. A Seganti et al. Searching for feasible stationary states in reaction networks by solving a Boolean constraint satisfaction problem. Phys Rev E 89:022139 (2014). DOI: 1103/PhysRevE.89.022139

    Other Selected Publications:

    1. FA Massucci et al, Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective. BMC Sys Biol 7:103 (2013). DOI:   1186/1752-0509-7-103
    2. M Figliuzzi et al, MicroRNAs as a selective channel of communication between competing RNAs, Biophys J 104:1203 (2013). DOI: 1016/j.bpj.2013.01.012
    3. A Seganti et al. Boolean constraint satisfaction problems for reaction networks, J Stat Mech P09009 (2013). DOI: 10.1088/1742-5468/2013/09/P09009
    4. D De Martino et al. Counting and correcting thermodynamically infeasible flux cycles in genome-scale metabolic networks, Metabolites 3:946 (2013). DOI: 3390/metabo3040946
    5. FA Massucci et al. A novel methodology to estimate metabolic flux distributions in constraint-based models, Metabolites 3:838 (2013). DOI: 3390/metabo3030838
    6. Evoli, Guzzi, B. Rizzuti, Dynamics and unfolding pathway of chimeric azurin variants: insights from molecular dynamics simulation, Journal of Biological Inorganic Chemistry, 18, 739-749, (2013) doi: 10.1007/s00775-013-1017-1
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