ToMA Lab – Tomography for Medical Application

Mission

• Researchmainly focused on the progress and translation of modern x-ray physics concepts to biomedical sciences, exploiting the long-standing experience in X-ray optics and X-ray imaging.
• Education for Diploma, and PhDstudentsinterested in biomedicalimaging and x-rayoptics

Link http://www.sapienza-cnrnanotec.it/tomalab/index.html

People Involved

Alessia

Cedola

CNR Researcher

Group Coordinator 

Fabrizio

Bardelli

Associate Researcher, Marie-Curie

Inna

Bukreeva

CNR Researcher

Francesco

Brun

Associate PostDoc

Michela

Fratini

CNR Researcher

Lorenzo

Massimi

Associate PostDoc

Facilities & Labs

Advanced X-ray @ Roma

Linee di Ricerca

Publications

  1. Recent advances in superhydrophobic surfaces and their relevance to biology and medicine.Ciasca G., Papi M., Businaro L., Campi G., Ortolani M., Palmieri V., Cedola A., De Ninno A., Gerardino A., Maulucci G., De Spirito M. . Bioinspiration&biomimetics 11 (1), 011001, 2016.
  2. Virtual unrolling and deciphering of Herculaneumpapyri by X-rayphase-contrasttomography, I. Bukreeva et al. Scientific Reports6, Article number: 27227 (2016).http://www.nature.com/articles/srep27227.
  3. Characterization of mouse spinalcordvascular network by means of synchrotronradiation X-rayphasecontrasttomography, L. Massimi et al, Physica Medica 2016, http://dx.doi.org/10.1016/j.ejmp.2016.09.015.
  4. X-ray micro-beam techniques and phase contrast tomography applied to biomaterials. Fratini M., Campi G., Bukreeva I., Pelliccia D., Burghammer M., Tromba G., Cancedda R., Mastrogiacomo M., Cedola A. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 364, 93-97, 2015.
  5. Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord. Michela Fratini, Inna Bukreeva, Gaetano Campi, Francesco Brun, Giuliana Tromba, Peter Modregger, Domenico Bucci, Giuseppe Battaglia, Raffaele Spadon, Maddalena Mastrogiacomo, HerwigRequardt, Federico Giove, Alberto Bravin, Alessia Cedola. Scientific Reports 5, 8514, 2015.http://www.nature.com/articles/srep08514.
  6. Imaging collagen packing dynamics during mineralization of engineered bone tissue. Campi, G., Fratini, M., Bukreeva, I., Ciasca, G., Burghammer, M., Brun, F., … & Cedola, A. Acta biomaterialia, 23, 309-316, 2015.
  7. High-resolution X-ray techniques as new tool to investigate the 3D vascularization of engineered-bone tissue. Bukreeva, I., Fratini, M., Campi, G., Pelliccia, D., Spanò, R., Tromba, G., … & Cedola, A. Frontiers in bioengineering and biotechnology, 3, 133, 2015.
  8. G.Campi,M.Fratini,I.Bukreeva,G.Ciasca,M.Burghammer,F.Brun,G.Tromba, M.Mastrogiacomo, andA.Cedola,Imagingcollagenpackingdynamicsduringmineralizationof engineeredbonetissue ACTA BIOMATERIALIA  Volume: 23   Pages: 309-316   Published: SEP 1 2015

Projects

• Europeanproject VOXEL “VolumetricMedical X-RayImagingatextremelylow dose” (HORIZON 2020-Fet Open; Project reference: 665207).
• BiominAB-3D – Revealing the composition and formationmechanism of carcinogenicasbestosbodies in human lungs; MSCA-IF-2015-EF – Marie Skłodowska-Curie IndividualFellowships (IF-EF), Marie Skłodowska-Curie IndividualFellowships (2016-2018)

Latest News

  • Scholar-in-Training Award dell’AACR a Marta Cavo

    Lecce, 15/01/2020
    Marta Cavo, ERC-postdoctoral research fellow at the CNR Institute of Nanotechnology in Lecce (ERC-StG INTERCELLMED No., 759959, PI: Dr. Loretta L. del Mercato), have been selected to receive a Scholar-in-Training Award (USD $625). The Scholarship will support her attendance at the Conference on The Evolving Landscape of Cancer Modeling, organized by the American Association for Cancer Research (AACR), to be held on 2-5 March 2020 in San Diego (California), where she will present the work “Quantifying stroma-tumor cell interactions in three-dimensional cell culture systems”. (more…)
  • I° meeting TecnoMed Puglia

    Lecce, 05 dicembre 2019 – Aula Rita Levi Montalcini – CNR NANOTEC Lecce

    Si terrà domani, giovedì 05 dicembre, con inizio alle ore 14.00 presso l’aula Rita Levi Montalcini del Cnr Nanotec, il “I° meeting TecnoMed Puglia: Tecnopolo per la medicina di precisione“. Il meeting mira a fare il punto sulle attività programmate, sullo stato di avanzamento e sugli highlights.

    Puoi scaricare la locandina da qui

  • Jam session Nanotec… note di scienza su scala nanometrica

    Lecce, 27 settembre 2019 – ex monastero degli Olivetani “CAR-T: l’alba di una nuova era”  con: Attilio Guarini (IRCCS Istituto Tumori “Giovanni Paolo II” di Bari)  introduce e modera: Marco Ferrazzoli (Ufficio Stampa CNR Roma) a cura di: Gabriella Zammillo 

    Le CAR-T (Chimeric Antigens Receptor Cells-T) sono cellule modificate in laboratorio a partire dai linfociti T. Rappresentano una nuova strategia di cura che sfrutta il sistema immunitario per combattere alcuni tipi di tumore come linfomi aggressivi a grandi cellule e leucemie linfoblastiche acute a cellule B. Il prof Attilio Guarini, ematologo all’Istituto tumori Giovanni Paolo II di Bari, le definisce la “vis sanatrix naturae della antica medicina salernitana”, trattandosi del potenziamento dell’attività citotossica dei linfociti del paziente opportunamente ingegnerizzati per riconoscere e contrastare alcuni tipi di cellule tumorali.

    (more…)