(a) Sphere-plane confinement geometry is used in SFA and AFM force measurements on proteins and other chain-like molecules. Adhesive groups such as the DOPA in Perna Viridis foot protein (PVFP) create a network of surface bridges. (b) AFM force measurement on a biomimetic adhesive polymer inspired to PVFPs-. The small probe radius R 10 nm allows resolving single bridge stretching and bond rupture events as well as the adhesion force F0. (c) SFA with R 2cm measures the force generated by a large population of molecules. (d) Single protein morphology and aggregate topology of lubricating BSM molecules resolved by AFM on flat mica surface.